Defining language networks from resting-state fMRI for surgical planning—a feasibility study

Authors

  • Yanmei Tie,

    Corresponding author
    1. Harvard Medical School, Boston, Massachusetts, USA
    2. Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts, USA
    • Department of Neurosurgery, Brigham and Women's Hospital, 75 Francis Street, CA 102, Boston, Massachusetts 02115. E-mail: ytie@bwh.harvard.edu

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  • Laura Rigolo,

    1. Harvard Medical School, Boston, Massachusetts, USA
    2. Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts, USA
    3. Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA
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  • Isaiah H. Norton,

    1. Harvard Medical School, Boston, Massachusetts, USA
    2. Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts, USA
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  • Raymond Y. Huang,

    1. Harvard Medical School, Boston, Massachusetts, USA
    2. Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA
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  • Wentao Wu,

    1. Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts, USA
    2. Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China
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  • Daniel Orringer,

    1. Harvard Medical School, Boston, Massachusetts, USA
    2. Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts, USA
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  • Srinivasan Mukundan Jr.,

    1. Harvard Medical School, Boston, Massachusetts, USA
    2. Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA
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  • Alexandra J. Golby

    1. Harvard Medical School, Boston, Massachusetts, USA
    2. Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts, USA
    3. Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA
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Abstract

Presurgical language mapping for patients with lesions close to language areas is critical to neurosurgical decision-making for preservation of language function. As a clinical noninvasive imaging technique, functional MRI (fMRI) is used to identify language areas by measuring blood-oxygen-level dependent (BOLD) signal change while patients perform carefully timed language vs. control tasks. This task-based fMRI critically depends on task performance, excluding many patients who have difficulty performing language tasks due to neurologic deficits. On the basis of recent discovery of resting-state fMRI (rs-fMRI), we propose a “task-free” paradigm acquiring fMRI data when patients simply are at rest. This paradigm is less demanding for patients to perform and easier for technologists to administer. We investigated the feasibility of this approach in right-handed healthy control subjects. First, group independent component analysis (ICA) was applied on the training group (14 subjects) to identify group level language components based on expert rating results. Then, four empirically and structurally defined language network templates were assessed for their ability to identify language components from individuals' ICA output of the testing group (18 subjects) based on spatial similarity analysis. Results suggest that it is feasible to extract language activations from rs-fMRI at the individual subject level, and two empirically defined templates (that focuses on frontal language areas and that incorporates both frontal and temporal language areas) demonstrated the best performance. We propose a semi-automated language component identification procedure and discuss the practical concerns and suggestions for this approach to be used in clinical fMRI language mapping. Hum Brain Mapp 35:1018–1030, 2014. © 2013 Wiley Periodicals, Inc.

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