National Institute of Neurologic Disorders and Stroke (K23NS062148); the National Institute of Nursing Research (R01NR010827), the National Institute on Aging (P60AG08812 and P01AG004390); and by Medical Research Service VA.
Associations between T1 white matter lesion volume and regional white matter microstructure in aging
Article first published online: 30 JAN 2013
Copyright © 2013 Wiley Periodicals, Inc.
Human Brain Mapping
Volume 35, Issue 3, pages 1085–1100, March 2014
How to Cite
Leritz, E. C., Shepel, J., Williams, V. J., Lipsitz, L. A., McGlinchey, R. E., Milberg, W. P. and Salat, D. H. (2014), Associations between T1 white matter lesion volume and regional white matter microstructure in aging. Hum. Brain Mapp., 35: 1085–1100. doi: 10.1002/hbm.22236
- Issue published online: 7 FEB 2014
- Article first published online: 30 JAN 2013
- Manuscript Accepted: 11 NOV 2012
- Manuscript Revised: 16 OCT 2012
- Manuscript Received: 22 DEC 2011
- National Institute of Neurologic Disorders and Stroke. Grant Number: K23NS062148
- National Institute of Nursing Research. Grant Number: R01NR010827
- National Institute on Aging. Grant Number: P60AG08812 and P01AG004390
- Medical Research Service VA (Merit Review Awards to W.M. and R.McG.)
- white matter lesions;
- white matter microstructure;
- diffusion tensor imaging
White matter lesions, typically manifesting as regions of signal intensity abnormality (WMSA) on MRI, increase in frequency with age. However, the role of this damage in cognitive decline and disease is still not clear, as lesion volume has only loosely been associated with clinical status. Diffusion tensor imaging (DTI) has been used to examine the quantitative microstructural integrity of white matter, and has applications in the examination of subtle changes to tissue that appear visually normal on conventional imaging. The primary goal of this study was to determine whether major macrostructural white matter damage, (total WMSA volume), is associated with microstructural integrity of normal appearing white matter, and if these macrostructural changes fully account for microstructural changes. Imaging was performed in 126 nondemented individuals, ages 43–85 years, with no history of cerebrovascular disease. Controlling for age, greater WMSA volume was associated with decreased fractional anisotropy (FA) in widespread brain regions. Patterns were similar for FA and radial diffusivity but in contrast, WMSA was associated with axial diffusivity in fewer areas. Age was associated with FA in several regions, and many of these effects remained even when controlling for WMSA volume, suggesting the etiology of WMSAs does not fully account for all age-associated white matter deterioration. These results provide evidence that WMSA volume is associated with the integrity of normal-appearing white matter. In addition, our results suggest that overt lesions may not account for the association of increasing age with decreased white matter tissue integrity. Hum Brain Mapp 35:1085–1100, 2014. © 2013 Wiley Periodicals, Inc.