This article was published online on 18 February 2013. An error was subsequently identified. This notice is included in the online and print versions to indicate that both have been corrected 13 December 2013.
Altered relationship between electrophysiological response to errors and gray matter volumes in an extended network for error-processing in pediatric obsessive-compulsive disorder
Version of Record online: 18 FEB 2013
Copyright © 2013 Wiley Periodicals, Inc.
Human Brain Mapping
Volume 35, Issue 4, pages 1143–1153, April 2014
How to Cite
Liu, Y., Hanna, G. L., Carrasco, M., Gehring, W. J. and Fitzgerald, K. D. (2014), Altered relationship between electrophysiological response to errors and gray matter volumes in an extended network for error-processing in pediatric obsessive-compulsive disorder. Hum. Brain Mapp., 35: 1143–1153. doi: 10.1002/hbm.22240
- Issue online: 20 MAR 2014
- Version of Record online: 18 FEB 2013
- Manuscript Accepted: 15 NOV 2012
- Manuscript Revised: 14 NOV 2012
- Manuscript Received: 10 JUL 2012
- National Institute of Mental Health. Grant Numbers: R01 MH086321, F31 MH086273, K23 MH082176
- International OCD Foundation, Dana Foundation, National Alliance for Research on Schizophrenia and Depression Young Investigator Award
- pediatric obsessive-compulsive disorder;
- event-related potential (ERP);
- error processing;
- voxel-based morphometry (VBM);
- magnetic resonance imaging (MRI)
Pediatric patients with obsessive-compulsive disorder (OCD) show an increased electrophysiological response to errors that is thought to be localized to the posterior medial prefrontal cortex (pMFC). However, the relation of this response, the error-related negativity (ERN), to underlying brain structures remains unknown. In an examination of 20 pediatric OCD patients and 20 healthy youth, we found that more negative ERN amplitude was correlated with lower gray matter (GM) density in pMFC and orbital frontal cortex. The association of the ERN with pMFC gray matter volume was driven by the patient group. In addition, a group difference in the association of ERN with gray matter in right insula was observed, showing an association of these measures in healthy youth (more negative ERN amplitude was associated with lower GM density in insula), but not in patients. These findings provide preliminary evidence linking gray matter volumes in an extended network for error processing to the ERN, and suggest that structural alterations in this network may underlie exaggeration of the ERN in pediatric OCD. Hum Brain Mapp 35:1143–1153, 2014. © 2013 Wiley Periodicals, Inc.