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FilenameFormatSizeDescription
hbm22257-sup-0001-SuppFig1.tif2252KSupporting Information Figure 1. Patient P1. A) Pre-operative deterministic tractography reconstructions superimposed on axial T1-weighted images; SLF I fibers are depicted in green, SLF II in blue, SLF III (that includes fibers of the horizontal part of the AF) in yellow and AF in red. White asterisks show the DES site of the SLF II, which caused a rightward bisection error during intraoperative stimulation. SLF II fibers are displaced laterally by the tumor. B) Postoperative MR tractography analysis on preoperative DTI acquisitions, with FA threshold > 0.2. White circles: starting ROIs for tractography reconstructions positioned in the sites of positive stimulation regions: depiction of the blue fibers, corresponding to the SLF II, at a higher and less “permissive” FA threshold. C) Post-operative probabilistic tractography superimposed on axial, coronal and sagittal T1-weighted images; tracking of parieto-frontal connections from stimulation sites (the red line depicts the seed mask on axial sections). Voxels are color-coded from 20 (blue) to 200 (light blue) samples passing through the voxel. Multi-fiber tractography identifies dorsal and lateral parieto-frontal connections linking the inferior parietal lobule to the posterior regions of the superior and middle frontal gyri, belonging to the SLF II.
hbm22257-sup-0001-SuppFig2.tif2252KSupporting Information Figure 2. Patient P2. A) Pre-operative deterministic tractography reconstructions superimposed on axial T1-weighted images (color code idem as in figure 1) in left-brain-damaged patient P2. SLF II fibers are difficult to be distinguished from AF fibers. White asterisks show the DES site of the SLF II. P2 showed no visuo-spatial neglect during DES. B) Postoperative MR tractography analysis on preoperative DTI acquisitions, with FA threshold > 0.2. Starting ROIs for tractography reconstructions were positioned in the sites of DES stimulation regions. SLF II fibers run very closely to AF fibers. C) Post-operative probabilistic tractography superimposed on axial, coronal and sagittal T1-weighted images; tracking of connections from stimulation sites (the red line depicts the seed mask on axial sections). Voxels are color-coded from 20 (blue) to 150 (light blue) samples passing through the voxel. Multi-fiber tractography identifies lateral fronto-temporal connections probably belonging to the AF.
hbm22257-sup-0001-SuppFig3.tif2252KSupporting Information Figure 3. Patient P3. A) Pre-operative deterministic tractography reconstructions superimposed on axial T1-weighted images (color code idem as in figure 1). White asterisks show the DES site of the SLF II, which caused a rightward bisection error during intraoperative stimulation. SLF II fibers pass through the hypo-intense tumoral tissue area, and are infiltrated by the tumor. B) Postoperative MR tractography analysis on preoperative DTI acquisitions, with FA threshold > 0.2. White circles: starting ROIs for tractography reconstructions positioned in the sites of positive stimulation regions. C) Post-operative probabilistic tractography superimposed on axial, coronal and sagittal T1-weighted images; tracking of parieto-frontal connections from stimulation sites (the red line depicts the seed mask on axial sections). Voxels are color-coded from 20 (blue) to 150 (light blue) samples passing through the voxel. Multi-fiber tractography identifies dorsal and lateral parieto-frontal connections belonging to the SLF II.
hbm22257-sup-0001-SuppFig4.tif2252KSupporting Information Figure 4. Patient P5. A) Pre-operative deterministic tractography reconstructions superimposed on axial T1-weighted images (color code idem as in figure 1). White asterisks show the DES site of the SLF II, which caused a rightward bisection error during intraoperative stimulation. SLF II fibers are displaced medially and superiorly by the tumor. B) Postoperative MR tractography analysis on preoperative DTI acquisitions, FA threshold > 0.2. White circles: starting ROIs for tractography reconstructions positioned in the sites of positive stimulation regions; depiction of the blue fibers, corresponding to the SLF II. C) Post-operative probabilistic tractography superimposed on axial, coronal and sagittal T1-weighted images; tracking of parieto-frontal connections from stimulation sites (the red line depicts the seed mask on axial sections). Voxels are color-coded from 20 (blue) to 200 (light blue) samples passing through the voxel. Multi-fiber tractography identifies dorsal and lateral parieto-frontal connections linking the inferior parietal lobule to the posterior regions of the superior and middle frontal gyri, belonging to the SLF II.
hbm22257-sup-0001-SuppFig5.tif2255KSupporting Information Figure 5. Patient P7. A) Pre-operative deterministic tractography reconstructions superimposed on axial T1-weighted images (color code idem as in figure 1). White asterisks show the DES site of the SLF II, which caused a rightward bisection error during intraoperative stimulation. SLF II fibers lie laterally to the tumor. B) Postoperative MR tractography analysis on preoperative DTI acquisitions, FA threshold > 0.2. White circles: starting ROIs for tractography reconstructions positioned in the sites of positive stimulation regions: depiction of the blue fibers, corresponding to the SLF II. C) Post-operative probabilistic tractography superimposed on axial, coronal and sagittal T1-weighted images; tracking of parieto-frontal connections from stimulation sites (the red line depicts the seed mask on axial sections). Voxels are color-coded from 20 (blue) to 200 (light blue) samples passing through the voxel. Multi-fiber tractography identifies dorsal and lateral parieto-frontal connections linking the inferior parietal lobule to the posterior regions of the superior and middle frontal gyri, belonging to the SLF II.
hbm22257-sup-0001-SuppInfo.docx129KSupporting Information
hbm22257-sup-0001-SuppTab1I.doc61KSupporting Information Table 1.

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