Gray and white matter correlates of navigational ability in humans

Authors

  • Joost Wegman,

    Corresponding author
    1. Behavioural Science Institute, Radboud University Nijmegen, Postbus, The Netherlands
    2. Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, The Netherlands
    • Correspondence to: Joost Wegman; Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. E-mail: joost.wegman@donders.ru.nl

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  • Hubert M. Fonteijn,

    1. Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, The Netherlands
    2. Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands
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  • Janneke van Ekert,

    1. Behavioural Science Institute, Radboud University Nijmegen, Postbus, The Netherlands
    2. Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, The Netherlands
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  • Anna Tyborowska,

    1. Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, The Netherlands
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  • Clemens Jansen,

    1. Behavioural Science Institute, Radboud University Nijmegen, Postbus, The Netherlands
    2. Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, The Netherlands
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  • Gabriele Janzen

    1. Behavioural Science Institute, Radboud University Nijmegen, Postbus, The Netherlands
    2. Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, The Netherlands
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Abstract

Humans differ widely in their navigational abilities. Studies have shown that self-reports on navigational abilities are good predictors of performance on navigation tasks in real and virtual environments. The caudate nucleus and medial temporal lobe regions have been suggested to subserve different navigational strategies. The ability to use different strategies might underlie navigational ability differences. This study examines the anatomical correlates of self-reported navigational ability in both gray and white matter. Local gray matter volume was compared between a group (N = 134) of good and bad navigators using voxel-based morphometry (VBM), as well as regional volumes. To compare between good and bad navigators, we also measured white matter anatomy using diffusion tensor imaging (DTI) and looked at fractional anisotropy (FA) values. We observed a trend toward higher local GM volume in right anterior parahippocampal/rhinal cortex for good versus bad navigators. Good male navigators showed significantly higher local GM volume in right hippocampus than bad male navigators. Conversely, bad navigators showed increased FA values in the internal capsule, the white matter bundle closest to the caudate nucleus and a trend toward higher local GM volume in the caudate nucleus. Furthermore, caudate nucleus regional volume correlated negatively with navigational ability. These convergent findings across imaging modalities are in line with findings showing that the caudate nucleus and the medial temporal lobes are involved in different wayfinding strategies. Our study is the first to show a link between self-reported large-scale navigational abilities and different measures of brain anatomy. Hum Brain Mapp 35:2561–2572, 2014. © 2013 Wiley Periodicals, Inc.

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