Functional dissociation of ventral frontal and dorsomedial default mode network components during resting state and emotional autobiographical recall

Authors

  • Patricia Bado,

    1. Cognitive and Behavioral Neuroscience Unit, D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil
    2. Instituto de Ciências Biomédicas (ICB), Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
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  • Annerose Engel,

    1. Cognitive and Behavioral Neuroscience Unit, D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil
    2. Music Cognition and Action Group, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
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  • Ricardo de Oliveira-Souza,

    1. Cognitive and Behavioral Neuroscience Unit, D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil
    2. Gaffrée e Guinle University Hospital, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil
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  • Ivanei E. Bramati,

    1. Cognitive and Behavioral Neuroscience Unit, D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil
    2. Instituto de Ciências Biomédicas (ICB), Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
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  • Fernando F. Paiva,

    1. Cognitive and Behavioral Neuroscience Unit, D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil
    2. Centro de Imagens e Espectroscopia In Vivo por Ressonância Magnética (CIERMag), Instituto de Física de São Carlos, Universidade de São Paulo, São Carlos, Brazil
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  • Rodrigo Basilio,

    1. Cognitive and Behavioral Neuroscience Unit, D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil
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  • João R. Sato,

    1. Cognitive and Behavioral Neuroscience Unit, D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil
    2. Center for Mathematics, Computation, and Cognition, Universidade Federal do ABC, Santo André, Brazil
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  • Fernanda Tovar-Moll,

    1. Cognitive and Behavioral Neuroscience Unit, D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil
    2. Instituto de Ciências Biomédicas (ICB), Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
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  • Jorge Moll

    Corresponding author
    1. Cognitive and Behavioral Neuroscience Unit, D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil
    • Correspondence to: Jorge Moll, Cognitive and Behavioral Neuroscience Unit, D'Or Institute for Research and Education, Rua Diniz Cordeiro, 30/3° andar, Rio de Janeiro 22281-100, Brazil. E-mail: jorge.moll@idor.org

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Abstract

Humans spend a substantial share of their lives mind-wandering. This spontaneous thinking activity usually comprises autobiographical recall, emotional, and self-referential components. While neuroimaging studies have demonstrated that a specific brain “default mode network” (DMN) is consistently engaged by the “resting state” of the mind, the relative contribution of key cognitive components to DMN activity is still poorly understood. Here we used fMRI to investigate whether activity in neural components of the DMN can be differentially explained by active recall of relevant emotional autobiographical memories as compared with the resting state. Our study design combined emotional autobiographical memory, neutral memory and resting state conditions, separated by a serial subtraction control task. Shared patterns of activation in the DMN were observed in both emotional autobiographical and resting conditions, when compared with serial subtraction. Directly contrasting autobiographical and resting conditions demonstrated a striking dissociation within the DMN in that emotional autobiographical retrieval led to stronger activation of the dorsomedial core regions (medial prefrontal cortex, posterior cingulate cortex), whereas the resting state condition engaged a ventral frontal network (ventral striatum, subgenual and ventral anterior cingulate cortices) in addition to the IPL. Our results reveal an as yet unreported dissociation within the DMN. Whereas the dorsomedial component can be explained by emotional autobiographical memory, the ventral frontal one is predominantly associated with the resting state proper, possibly underlying fundamental motivational mechanisms engaged during spontaneous unconstrained ideation. Hum Brain Mapp 35:3302–3313, 2014. © 2013 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc..

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