Reduced anterior internal capsule white matter integrity in primary insomnia

Authors

  • Kai Spiegelhalder,

    Corresponding author
    1. Department of Psychiatry and Psychotherapy, University of Freiburg Medical Center, Freiburg, Germany
    2. Freiburg Institute of Advanced Studies (FRIAS), University of Freiburg, Germany
    • Correspondence to: Kai Spiegelhalder, University Medical Center Freiburg, Department of Psychiatry and Psychotherapy, Hauptstraße 5, 79104 Freiburg, Germany. E-mail: Kai.Spiegelhalder@uniklinik-freiburg.de

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    • Kai Spiegelhalder, Wolfram Regen, and Martin Prem contributed equally to this work.

  • Wolfram Regen,

    1. Department of Psychiatry and Psychotherapy, University of Freiburg Medical Center, Freiburg, Germany
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    • Kai Spiegelhalder, Wolfram Regen, and Martin Prem contributed equally to this work.

  • Martin Prem,

    1. Institute of Forensic and Traffic Medicine, University of Heidelberg, Heidelberg, Germany
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    • Kai Spiegelhalder, Wolfram Regen, and Martin Prem contributed equally to this work.

  • Chiara Baglioni,

    1. Department of Psychiatry and Psychotherapy, University of Freiburg Medical Center, Freiburg, Germany
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  • Christoph Nissen,

    1. Department of Psychiatry and Psychotherapy, University of Freiburg Medical Center, Freiburg, Germany
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  • Bernd Feige,

    1. Department of Psychiatry and Psychotherapy, University of Freiburg Medical Center, Freiburg, Germany
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  • Susanne Schnell,

    1. Department of Radiology, Northwestern University, Feinberg Medical School, Chicago, Illinois
    2. Department of Diagnostic Radiology, University of Freiburg Medical Center, Freiburg, Germany
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  • Valerij G. Kiselev,

    1. Department of Diagnostic Radiology, University of Freiburg Medical Center, Freiburg, Germany
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  • Jürgen Hennig,

    1. Department of Diagnostic Radiology, University of Freiburg Medical Center, Freiburg, Germany
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  • Dieter Riemann

    1. Department of Psychiatry and Psychotherapy, University of Freiburg Medical Center, Freiburg, Germany
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Abstract

Chronic insomnia is one of the most prevalent central nervous system diseases, however, its neurobiology is poorly understood. Up to now, nothing is known about the integrity of white matter tracts in insomnia patients. In this study, diffusion tensor imaging (DTI) was used in a well-characterized sample of primary insomnia (PI) patients and good sleeper controls to fill this void. Voxelwise between-group comparisons of fractional anisotropy (FA) were performed in 24 PI patients (10 males; 14 females; 42.7 ± 14.5 years) and 35 healthy good sleepers (15 males; 20 females; 40.1 ± 9.1 years) with age and sex as covariates. PI patients showed reduced FA values within the right anterior internal capsule and a trend for reduced FA values in the left anterior internal capsule. The results suggest that insomnia is associated with a reduced integrity of white matter tracts in the anterior internal capsule indicating that disturbed fronto-subcortical connectivity may be a cause or consequence of the disorder. Hum Brain Mapp 35:3431–3438, 2014. © 2013 Wiley Periodicals, Inc.

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