Abnormal salience network in normal aging and in amnestic mild cognitive impairment and Alzheimer's disease

Authors

  • Xiaoxi He,

    1. Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, China
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    • X.H., W.Q., and Y.L. contributed equally to this work.

  • Wen Qin,

    1. Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, China
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    • X.H., W.Q., and Y.L. contributed equally to this work.

  • Yong Liu,

    1. Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, China
    2. National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China
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    • X.H., W.Q., and Y.L. contributed equally to this work.

  • Xinqing Zhang,

    1. Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China
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  • Yunyun Duan,

    1. Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China
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  • Jinyu Song,

    1. Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, China
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  • Kuncheng Li,

    1. Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China
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  • Tianzi Jiang,

    1. Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, China
    2. National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China
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  • Chunshui Yu

    Corresponding author
    1. Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, China
    • Correspondence to: Chunshui Yu, Department of Radiology, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin 300052, China. E-mail: chunshuiyu@tijmu.edu.cn

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Abstract

The salience network (SN) serves to identify salient stimuli and to switch between the central executive network (CEN) and the default-mode network (DMN), both of which are impaired in Alzheimer's disease (AD)/amnestic mild cognitive impairment (aMCI). We hypothesized that both the structural and functional organization of the SN and functional interactions between the SN and CEN/DMN are altered in normal aging and in AD/aMCI. Gray matter volume (GMV) and resting-state functional connectivity (FC) were analyzed from healthy younger (HYC) to older controls (HOC) and from HOC to aMCI and AD patients. All the SN components showed significant differences in the GMV, intranetwork FC, and internetwork FC between the HYC and HOC. Most of the SN components showed differences in the GMV between the HOC and AD and between the aMCI and AD. Compared with the HOC, AD patients exhibited significant differences in intra- and internetwork FCs of the SN, whereas aMCI patients demonstrated differences in internetwork FC of the SN. Most of the GMVs and internetwork FCs of the SN and part of the intranetwork FC of the SN were correlated with cognitive differences in older subjects. Our findings suggested that structural and functional impairments of the SN may occur as early as in normal aging and that functional disconnection between the SN and CEN/ DMN may also be associated with both normal aging and disease progression. Hum Brain Mapp 35:3446–3464, 2014. © 2013 Wiley Periodicals, Inc.

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