The authors have no actual or potential conflicts of interest to disclose.
Aging effects on the resting state motor network and interlimb coordination
Article first published online: 22 JAN 2014
Copyright © 2014 Wiley Periodicals, Inc.
Human Brain Mapping
Volume 35, Issue 8, pages 3945–3961, August 2014
How to Cite
Solesio-Jofre, E., Serbruyns, L., Woolley, D. G., Mantini, D., Beets, I. A. M. and Swinnen, S. P. (2014), Aging effects on the resting state motor network and interlimb coordination. Hum. Brain Mapp., 35: 3945–3961. doi: 10.1002/hbm.22450
This protocol was approved by the local ethics committee for biomedical research and subjects gave written informed consent prior to participation.
- Issue published online: 8 JUL 2014
- Article first published online: 22 JAN 2014
- Manuscript Accepted: 2 DEC 2013
- Manuscript Revised: 29 NOV 2013
- Manuscript Received: 21 OCT 2013
- Interuniversity Attraction Poles Programme initiated by the Belgian Science Policy. Grant Number: P7/11
- Research Fund KU Leuven. Grant Number: OT/11/071
- FWO Vlaanderen. Grant Numbers: G.0483.10, G.0721.12
- 7th European Union Framework programme. Grant Number: PCIG12-GA-2012-334039
- resting state;
- motor network;
- bimanual coordination;
- functional connectivity
Both increases and decreases in resting state functional connectivity have been previously observed within the motor network during aging. Moreover, the relationship between altered functional connectivity and age-related declines in bimanual coordination remains unclear. Here, we explored the developmental dynamics of the resting brain within a task-specific motor network in a sample of 128 healthy participants, aged 18–80 years. We found that age-related increases in functional connectivity between interhemispheric dorsal and ventral premotor areas were associated with poorer performance on a novel bimanual visuomotor task. Additionally, a control analysis performed on the default mode network confirmed that our age-related increases in functional connectivity were specific to the motor system. Our findings suggest that increases in functional connectivity within the resting state motor network with aging reflect a loss of functional specialization that may not only occur in the active brain but also in the resting brain. Hum Brain Mapp 35:3945–3961, 2014. © 2014 Wiley Periodicals, Inc.