The neural correlates of worry in association with individual differences in neuroticism
Article first published online: 14 FEB 2014
Copyright © 2014 Wiley Periodicals, Inc.
Human Brain Mapping
Volume 35, Issue 9, pages 4303–4315, September 2014
How to Cite
Servaas, M. N., Riese, H., Ormel, J. and Aleman, A. (2014), The neural correlates of worry in association with individual differences in neuroticism. Hum. Brain Mapp., 35: 4303–4315. doi: 10.1002/hbm.22476
- Issue published online: 18 JUL 2014
- Article first published online: 14 FEB 2014
- Manuscript Accepted: 16 JAN 2014
- Manuscript Revised: 29 OCT 2013
- Manuscript Received: 5 JUL 2013
- Ministry of Education, Culture and Science of the Netherlands. Grant Number: 609022.
- autobiographical specificity;
- cognitive avoidance;
- default mode network;
- mood induction paradigm;
- retrosplenial and visual cortex;
- visual mental imagery
The tendency to worry is a facet of neuroticism that has been shown to mediate the relationship between neuroticism and symptoms of depression and anxiety. The aim of the current study was to investigate the neural correlates of state worry in association with neuroticism. One-hundred twenty participants were selected from an initially recruited sample of 240 women based on their neuroticism score. First, participants completed a questionnaire to assess the excessiveness and uncontrollability of pathological worry. Second, we measured brain activation with functional magnetic resonance imaging (fMRI) while participants were randomly presented with 12 worry-inducing sentences and 12 neutral sentences in a mood induction paradigm. Individuals scoring higher on neuroticism reported to worry more in daily life and to have generated more worry-related thoughts after the presentation of a worry-inducing sentence. Furthermore, imaging results showed the involvement of default mode and emotional brain areas during worry, previously associated with self-related processing and emotion regulation. Specifically, cortical midline structures and the anterior insula showed more activation during worry, when individuals indicated to have generated more worry-related thoughts. Activation in the retrosplenial and visual cortex was decreased in individuals scoring higher on neuroticism during worry, possibly suggesting reduced autobiographical specificity and visual mental imagery. In the literature, both these processes have been related to the cognitive avoidance of emotional distress. Excessive worry features in a number of emotional disorders and results from studies that elucidate its neural basis may help explain how and why neuroticism contributes to vulnerability for psychopathology. Hum Brain Mapp 35:4303–4315, 2014. © 2014 Wiley Periodicals, Inc.