L.H.v.d.B. and M.P.v.d.H. contributed equally to this work.
Correlation between structural and functional connectivity impairment in amyotrophic lateral sclerosis
Version of Record online: 6 MAR 2014
Copyright © 2014 The Authors. Human Brain Mapping Published by Wiley Periodicals, Inc.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Human Brain Mapping
Volume 35, Issue 9, pages 4386–4395, September 2014
How to Cite
Schmidt, R., Verstraete, E., de Reus, M. A., Veldink, J. H., van den Berg, L. H. and van den Heuvel, M. P. (2014), Correlation between structural and functional connectivity impairment in amyotrophic lateral sclerosis. Hum. Brain Mapp., 35: 4386–4395. doi: 10.1002/hbm.22481
- Issue online: 18 JUL 2014
- Version of Record online: 6 MAR 2014
- Manuscript Accepted: 21 JAN 2014
- Manuscript Revised: 21 DEC 2013
- Manuscript Received: 2 OCT 2013
- amyotrophic lateral sclerosis;
- magnetic resonance imaging;
- diffusion weighted imaging;
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, characterized by progressive loss of motor function. While the pathogenesis of ALS remains largely unknown, imaging studies of the brain should lead to more insight into structural and functional disease effects on the brain network, which may provide valuable information on the underlying disease process. This study investigates the correlation between changes in structural connectivity (SC) and functional connectivity (FC) of the brain network in ALS. Structural reconstructions of the brain network, derived from diffusion weighted imaging (DWI), were obtained from 64 patients and 27 healthy controls. Functional interactions between brain regions were derived from resting-state fMRI. Our results show that (i) the most structurally affected connections considerably overlap with the most functionally impaired connections, (ii) direct connections of the motor cortex are both structurally and functionally more affected than connections at greater topological distance from the motor cortex, and (iii) there is a strong positive correlation between changes in SC and FC averaged per brain region (r = 0.44, P < 0.0001). Our findings indicate that structural and functional network degeneration in ALS is coupled, suggesting the pathogenic process affects both SC and FC of the brain, with the most prominent effects in SC. Hum Brain Mapp 35:4386–4395, 2014. © 2014 The Authors. Human Brain Mapping Published by Wiley Periodicals, Inc.