L.H.v.d.B. and M.P.v.d.H. contributed equally to this work.
Correlation between structural and functional connectivity impairment in amyotrophic lateral sclerosis
Version of Record online: 6 MAR 2014
Copyright © 2014 The Authors. Human Brain Mapping Published by Wiley Periodicals, Inc.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Human Brain Mapping
Volume 35, Issue 9, pages 4386–4395, September 2014
How to Cite
Schmidt, R., Verstraete, E., de Reus, M. A., Veldink, J. H., van den Berg, L. H. and van den Heuvel, M. P. (2014), Correlation between structural and functional connectivity impairment in amyotrophic lateral sclerosis. Hum. Brain Mapp., 35: 4386–4395. doi: 10.1002/hbm.22481
- Issue online: 18 JUL 2014
- Version of Record online: 6 MAR 2014
- Manuscript Accepted: 21 JAN 2014
- Manuscript Revised: 21 DEC 2013
- Manuscript Received: 2 OCT 2013
Additional Supporting Information may be found in the online version of this article.
|hbm22481-sup-0001-suppfig1.tif||14534K||Figure S1. Nodes connected to the left motor cortex are displayed in rings with a radius proportional to the topological distance from the left motor cortex. Connections in red or green correspond to structural or functional impairments, respectively. (1) and (2) mark the first and second ring of nodes surrounding the motor cortex. The anatomical distribution of the cortical first and second ring nodes is shown in the medial and lateral brain images. First and second ring nodes are listed in Table S-I, starting from (1) and (2) going round clockwise.|
|hbm22481-sup-0002-suppfig2.tif||4319K||Figure S2. SC and FC differences in patients at increasing topological distance from the left motor cortex. (*) denotes significant differences between healthy controls and patients, (**) indicates impairment of the first and second ring differ significantly.|
|hbm22481-sup-0003-suppfig3.tif||57575K||Figure S3. Scatter plot of ALSFRS-R scores vs. first ring SC (a, b, e, f) and FC (c, d, g, h) impairments of the left and right motor cortices. (*) denotes statistical significance of the correlation (P = 0.02).|
|hbm22481-sup-0004-suppfig4.tif||16979K||Figure S4. Scatter plot of changes in FA and FC in direct connections of the whole brain (a) and of the motor cortex alone (b), fitted by a straight line. Positive connectivity changes denote impairments and negative connectivity changes mark enhancements. (*) denotes statistical significance of the correlation (P < 0.0001).|
|hbm22481-sup-0005-supptable1.doc||30K||Table S-I. Ring classification of cortical and sub-cortical nodes surrounding the left motor cortex.|
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