Additional Supporting Information may be found in the online version of this article.

hbm22481-sup-0001-suppfig1.tif14534KFigure S1. Nodes connected to the left motor cortex are displayed in rings with a radius proportional to the topological distance from the left motor cortex. Connections in red or green correspond to structural or functional impairments, respectively. (1) and (2) mark the first and second ring of nodes surrounding the motor cortex. The anatomical distribution of the cortical first and second ring nodes is shown in the medial and lateral brain images. First and second ring nodes are listed in Table S-I, starting from (1) and (2) going round clockwise.
hbm22481-sup-0002-suppfig2.tif4319KFigure S2. SC and FC differences in patients at increasing topological distance from the left motor cortex. (*) denotes significant differences between healthy controls and patients, (**) indicates impairment of the first and second ring differ significantly.
hbm22481-sup-0003-suppfig3.tif57575KFigure S3. Scatter plot of ALSFRS-R scores vs. first ring SC (a, b, e, f) and FC (c, d, g, h) impairments of the left and right motor cortices. (*) denotes statistical significance of the correlation (P = 0.02).
hbm22481-sup-0004-suppfig4.tif16979KFigure S4. Scatter plot of changes in FA and FC in direct connections of the whole brain (a) and of the motor cortex alone (b), fitted by a straight line. Positive connectivity changes denote impairments and negative connectivity changes mark enhancements. (*) denotes statistical significance of the correlation (P < 0.0001).
hbm22481-sup-0005-supptable1.doc30KTable S-I. Ring classification of cortical and sub-cortical nodes surrounding the left motor cortex.
hbm22481-sup-0006-suppinfo.doc32Ksupporting Information

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