This article was published online on 27 February 2014. An error was subsequently identified. This notice is included in the online and print versions to indicate that both have been corrected 3 April 2014.
Altered structural brain connectome in young adult fragile X premutation carriers
Article first published online: 27 FEB 2014
Copyright © 2014 Wiley Periodicals, Inc.
Human Brain Mapping
Volume 35, Issue 9, pages 4518–4530, September 2014
How to Cite
Leow, A., Harvey, D., Goodrich-Hunsaker, N. J., Gadelkarim, J., Kumar, A., Zhan, L., Rivera, S. M. and Simon, T. J. (2014), Altered structural brain connectome in young adult fragile X premutation carriers. Hum. Brain Mapp., 35: 4518–4530. doi: 10.1002/hbm.22491
Conflict of Interest: The authors declare that they have no competing interests.
- Issue published online: 18 JUL 2014
- Article first published online: 27 FEB 2014
- Manuscript Accepted: 5 FEB 2014
- Manuscript Revised: 16 JAN 2014
- Manuscript Received: 18 OCT 2013
- National Institute of Health (NIH). Grant Numbers: NIA RL1 AG032119, NINDS RL1 NS062412, and NIDA TL1 DA024854
- Roadmap Initiative grant. Grant Number: UL1 DE019583
- National Institute of Dental and Craniofacial Research (NIDCR)
- structural connectome;
- graph theory;
- fragile X;
Fragile X premutation carriers (fXPC) are characterized by 55–200 CGG trinucleotide repeats in the 5′ untranslated region on the Xq27.3 site of the X chromosome. Clinically, they are associated with the fragile X-Associated Tremor/Ataxia Syndrome, a late-onset neurodegenerative disorder with diffuse white matter neuropathology. Here, we conducted first-ever graph theoretical network analyses in fXPCs using 30-direction diffusion-weighted magnetic resonance images acquired from 42 healthy controls aged 18–44 years (HC; 22 male and 20 female) and 46 fXPCs (16 male and 30 female). Globally, we found no differences between the fXPCs and HCs within each gender for all global graph theoretical measures. In male fXPCs, global efficiency was significantly negatively associated with the number of CGG repeats. For nodal measures, significant group differences were found between male fXPCs and male HCs in the right fusiform and the right ventral diencephalon (for nodal efficiency), and in the left hippocampus [for nodal clustering coefficient (CC)]. In female fXPCs, CC in the left superior parietal cortex correlated with counting performance in an enumeration task. Hum Brain Mapp 35:4518–4530, 2014. © 2014 Wiley Periodicals, Inc.