Statistical parametric maps in functional imaging: A general linear approach
Article first published online: 13 OCT 2004
Copyright © 1995 Wiley-Liss, Inc.
Human Brain Mapping
Volume 2, Issue 4, pages 189–210, 1994
How to Cite
Friston, K. J., Holmes, A. P., Worsley, K. J., Poline, J.-P., Frith, C. D. and Frackowiak, R. S. J. (1994), Statistical parametric maps in functional imaging: A general linear approach. Hum. Brain Mapp., 2: 189–210. doi: 10.1002/hbm.460020402
- Issue published online: 13 OCT 2004
- Article first published online: 13 OCT 2004
- Manuscript Accepted: 7 APR 1995
- Manuscript Received: 18 NOV 1994
- statistical parametric maps;
- analysis of variance;
- general linear model;
- functional imaging;
- Gaussian fields;
- functional anatomy
Statistical parametric maps are spatially extended statistical processes that are used to test hypotheses about regionally specific effects in neuroimaging data. The most established sorts of statistical parametric maps (e.g., Friston et al. : J Cereb Blood Flow Metab 11:690–699; Worsley et al. : J Cereb Blood Flow Metab 12:900–918) are based on linear models, for example ANCOVA, correlation coefficients and t tests. In the sense that these examples are all special cases of the general linear model it should be possible to implement them (and many others) within a unified framework. We present here a general approach that accomodates most forms of experimental layout and ensuing analysis (designed experiments with fixed effects for factors, covariates and interaction of factors). This approach brings together two well established bodies of theory (the general linear model and the theory of Gaussian fields) to provide a complete and simple framework for the analysis of imaging data.
The importance of this framework is twofold: (i) Conceptual and mathematical simplicity, in that the same small number of operational equations is used irrespective of the complexity of the experiment or nature of the statistical model and (ii) the generality of the framework provides for great latitude in experimental design and analysis. © 1995 Wiley-Liss, Inc.