Spatial registration and normalization of images
Article first published online: 13 OCT 2004
Copyright © 1995 Wiley-Liss, Inc.
Human Brain Mapping
Volume 3, Issue 3, pages 165–189, 1995
How to Cite
Friston, Karl. J., Ashburner, J., Frith, C. D., Poline, J.-B., Heather, J. D. and Frackowiak, R. S. J. (1995), Spatial registration and normalization of images. Hum. Brain Mapp., 3: 165–189. doi: 10.1002/hbm.460030303
- Issue published online: 13 OCT 2004
- Article first published online: 13 OCT 2004
- Manuscript Revised: 10 FEB 1995
- Manuscript Received: 28 JUL 1994
- basis functions;
- spatial normalization;
- functional mapping
This paper concerns the spatial and intensity transformations that map one image onto another. We present a general technique that facilitates nonlinear spatial (stereotactic) normalization and image realignment. This technique minimizes the sum of squares between two images following nonlinear spatial deformations and transformations of the voxel (intensity) values. The spatial and intensity transformations are obtained simultaneously, and explicitly, using a least squares solution and a series of linearising devices. The approach is completely noninteractive (automatic), nonlinear, and noniterative. It can be applied in any number of dimensions.
Various applications are considered, including the realignment of functional magnetic resonance imaging (MRI) time-series, the linear (affine) and nonlinear spatial normalization of positron emission tomography (PET) and structural MRI images, the coregistration of PET to structural MRI, and, implicitly, the conjoining of PET and MRI to obtain high resolution functional images. © 1995 Wiley-Liss, Inc.