Silica Boron Sulfuric Acid Nanoparticles: As an Efficient and Reusable Catalyst for the Large-Scale Synthesis of α-Amino Nitriles Using the Strecker Reaction


Correspondence to: Ali Khalafi-Nezhad; e-mail: Farhad Panahi; e-mail:


A highly efficient and green procedure for the large-scale synthesis of α-amino nitriles using three-component condensation of carbonyl compounds, amines, and trimethylsilylcyanide has been developed. Silica boron sulfuric acid nanoparticles (SBSANs) are found as an efficient heterogeneous catalyst for the promotion of this process at room temperature under solvent-free conditions. This protocol offers an effective and scale-up procedure for the synthesis of various α-amino nitriles using a wide range of amines and carbonyl compounds in relatively short reaction time with the excellent isolated yields. In addition, the SBSAN catalyst is easily separated from the reaction mixture by simple filtration and can be reused several times. © 2012 Wiley Periodicals, Inc. Heteroatom Chem 24:1–8, 2013; View this article online at DOI 10.1002/hc.21052