Health Economics Letter
Rational Centre Selection for RCTs with a Parallel Economic Evaluation—the Next Step Towards Increased Generalisability?
Version of Record online: 13 FEB 2014
Copyright © 2014 John Wiley & Sons, Ltd.
Volume 24, Issue 4, pages 498–504, April 2015
How to Cite
2015), Rational Centre SELECTION for RCTs with a Parallel Economic Evaluation—the Next Step Towards Increased Generalisability?, Health Econ., 24, 498–504, doi: 10.1002/hec.3039, , , , and (
- Issue online: 11 MAR 2015
- Version of Record online: 13 FEB 2014
- Manuscript Accepted: 14 JAN 2014
- Manuscript Revised: 9 DEC 2013
- Manuscript Received: 2 APR 2012
- economic evaluation;
- randomised controlled trials;
The paper discusses the impact of centre selection on the generalisability of randomised controlled trial (RCT)-based economic evaluations and suggests a future research agenda. The first section briefly reviews the current methods for addressing generalisability. We argue that these methods make no verifiable assumptions about how representative the recruiting centres are to the population of centres in the jurisdiction. The second section uses data from a multicentre RCT to illustrate that cost-effectiveness estimates can be influenced by the sample of recruiting centres. Finally, we propose two concepts that may advance generalisability research. First, we distinguish between the ‘research space’ and the ‘policy space’ and argue that policy makers are interested in the latter, while current methods describe the former. Second, we propose a centre-specific generalisability index used at RCT design stage to address generalisability. We conclude that future research should focus on generalisability at RCT design stage rather than on post hoc analyses. Copyright © 2014 John Wiley & Sons, Ltd.