Communicating the Parameter Uncertainty in the IQWiG Efficiency Frontier to Decision-Makers
Version of Record online: 4 MAR 2014
© 2014 The Authors. Health Economics published by John Wiley & Sons Ltd.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Volume 24, Issue 4, pages 481–490, April 2015
How to Cite
2015), Communicating the Parameter Uncertainty in the IQWiG Efficiency Frontier to Decision-Makers, Health Econ., 24, 481–490, doi: 10.1002/hec.3041, , , , , , , and (
- Issue online: 11 MAR 2015
- Version of Record online: 4 MAR 2014
- Manuscript Accepted: 19 JAN 2014
- Manuscript Revised: 3 JAN 2014
- Manuscript Received: 20 JUL 2012
- efficiency frontier;
- economic evaluation;
The Institute for Quality and Efficiency in Health Care (IQWiG) developed—in a consultation process with an international expert panel—the efficiency frontier (EF) approach to satisfy a range of legal requirements for economic evaluation in Germany's statutory health insurance system. The EF approach is distinctly different from other health economic approaches. Here, we evaluate established tools for assessing and communicating parameter uncertainty in terms of their applicability to the EF approach. Among these are tools that perform the following: (i) graphically display overall uncertainty within the IQWiG EF (scatter plots, confidence bands, and contour plots) and (ii) communicate the uncertainty around the reimbursable price. We found that, within the EF approach, most established plots were not always easy to interpret. Hence, we propose the use of price reimbursement acceptability curves—a modification of the well-known cost-effectiveness acceptability curves. Furthermore, it emerges that the net monetary benefit allows an intuitive interpretation of parameter uncertainty within the EF approach. This research closes a gap for handling uncertainty in the economic evaluation approach of the IQWiG methods when using the EF. However, the precise consequences of uncertainty when determining prices are yet to be defined. © 2014 The Authors. Health Economics published by John Wiley & Sons Ltd.