Costs, effects and C/E-ratios alongside a clinical trial
Article first published online: 18 SEP 2006
Copyright © 1994 John Wiley & Sons, Ltd.
Volume 3, Issue 5, pages 309–319, September/October 1994
How to Cite
Van Hout, B. A., Al, M. J., Gordon, G. S. and Rutten, F. F. H. (1994), Costs, effects and C/E-ratios alongside a clinical trial. Health Econ., 3: 309–319. doi: 10.1002/hec.4730030505
- Issue published online: 18 SEP 2006
- Article first published online: 18 SEP 2006
- Manuscript Accepted: 12 MAY 1994
- Manuscript Received: 14 JUL 1993
- Economic appraisal;
- confidence intervals;
- cost effectiveness ratio;
- sepsis syndrome
A general approach is discussed to assess the uncertainty surrounding the cost effectiveness ratio (C/E-ratio) estimated on the basis of data from a randomised clinical trial. The approach includes the calculation of a 95% probability ellipse and introduces the concept of a so called C/E-acceptability curve. This last curve defines for each predefined C/E-ratio the probability that the C/E-ratio found in the study is acceptable. The approach is illustrated by estimates of costs per life saved and costs per patient discharged alive on the basis of data from a phase II trial addressing the value of anakinra in treating sepsis syndrome.