Confidence intervals for cost/effectiveness ratios

Authors

  • Peter Wakker,

    1. Medical Decision Making Unit, University of Leiden, The Netherlands
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  • Dr. Marc P. Klaassen

    Corresponding author
    1. Medical Decision Making Unit, University of Leiden, The Netherlands
    • Medical Decision Making Unit, University of Leiden (AZL #l43), P.O. Box 9600, Leiden, 2300 RC, The Netherlands
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Abstract

The reduction of costs is becoming increasingly important in the medical field. The relevant topic of many clinical trials is not effectiveness per se, but rather cost-effectiveness ratios. Surprisingly, no statistical tools for analyzing cost-effectiveness ratios have been provided in the medical literature yet. This paper explains the gap in the literature, and provides a first technique for obtaining confidence intervals for cost-effectiveness ratios. The technique does not use sophisticated tools to achieve maximal optimality, but seeks for tractability and ease of application while still satisfying all formal statistical requirements.

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