Dennis H. Kraus, MD, Section Editor
Desmoplastic neurotropic melanoma of the head and neck: The role of radiation therapy†
Version of Record online: 28 OCT 2002
Copyright © 2002 Wiley Periodicals, Inc.
Head & Neck
Volume 24, Issue 12, pages 1068–1071, December 2002
How to Cite
Anderson, T. D., Weber, R. S., Guerry, D., Elder, D., Schuchter, L., Loevner, L. A. and Rosenthal, D. I. (2002), Desmoplastic neurotropic melanoma of the head and neck: The role of radiation therapy. Head Neck, 24: 1068–1071. doi: 10.1002/hed.10141
- Issue online: 26 NOV 2002
- Version of Record online: 28 OCT 2002
- Manuscript Accepted: 4 FEB 2002
- radiation therapy;
Desmoplastic neurotropic melanoma (DNM) is an uncommon cutaneous melanoma variant with pronounced neurotropism. In contrast to ordinary melanomas, locoregional recurrences are common and distant metastasis are uncommon in patients with DNM. Local control with surgery and radiation therapy may assume a more important role in this variant of melanoma. We present a case of an unresectable skull base recurrence of DNM that was controlled using radiation therapy alone and review the literature.
Case report with 36-month follow-up.
The patient is a 68-year-old with multiple recurrences of a DNM that originated on the forehead. After extensive surgery, including total parotidectomy and temporal bone resection, the patient had an unresectable recurrence of the skull base develop. This was treated with definitive radiation therapy, resulting in a complete response. The patient has had no evidence of recurrence at 3 years.
DNM is a locally aggressive type of melanoma with a high risk of local recurrence that can be radioresponsive. The incidence of distant metastasis is low, so aggressive treatment to control local disease is warranted. This may include surgery plus adjuvant radiation therapy or definitive radiotherapy for unresectable recurrences. © 2002 Wiley Periodicals, Inc.