From the Commission on Cancer at the American College of Surgeons, Chicago, Illinois, and the American Cancer Society, Atlanta, Georgia
Article first published online: 27 JUL 2004
Copyright © 2004 Wiley Periodicals, Inc.
Head & Neck
Volume 26, Issue 8, pages 660–674, August 2004
How to Cite
Zhen, W., Karnell, L. H., Hoffman, H. T., Funk, G. F., Buatti, J. M. and Menck, H. R. (2004), The national cancer data base report on squamous cell carcinoma of the base of tongue. Head Neck, 26: 660–674. doi: 10.1002/hed.20064
Reprint requests to: Weining Zhen, Department of Radiation Oncology and Department of Otolaryngology—Head and Neck Surgery, University of Nebraska Medical Center, 987521 Nebraska Medical Center, Omaha, NE 68198-7521
- Issue published online: 27 JUL 2004
- Article first published online: 27 JUL 2004
- Manuscript Accepted: 9 JAN 2004
- squamous cell carcinoma;
- base of tongue;
- disease characteristics;
- patterns of care;
- National Cancer Data Base (NCDB)
This study provides the largest contemporary overview of presentation, care, and outcome for base of tongue squamous cell carcinoma (SCC).
We extracted 16,188 cases from the National Cancer Data Base (NCDB). Chi-square analyses were performed on selected cross-tabulations. Observed and disease-specific survival were used to analyze outcome.
Three-quarters had advanced-stage (III–IV) disease. Radiation therapy alone (24.5%) and combined with surgery (26.9%) were the most common treatments. Five-year observed and disease-specific survival rates were 27.8% and 40.3%, respectively. Poorer survival was significantly associated with older age, low income, and advanced-stage disease. For early-stage disease, surgery with or without irradiation had higher survival than irradiation alone. For advanced-stage disease, surgery with irradiation had the highest survival.
Survival rates were low for base of tongue SCC, with most deaths occurring within the first 2 years. Income, stage, and age were significant prognostic factors. In this nonrandomized series, surgery with radiation therapy offered patients with advanced-stage disease the best survival. © 2004 Wiley Periodicals, Inc. Head Neck 26: 660–674, 2004