Importance of tumor thickness and depth of invasion in nodal involvement and prognosis of oral squamous cell carcinoma: A review of the literature
Article first published online: 20 OCT 2005
Copyright © 2005 Wiley Periodicals, Inc.
Head & Neck
Volume 27, Issue 12, pages 1080–1091, December 2005
How to Cite
Pentenero, M., Gandolfo, S. and Carrozzo, M. (2005), Importance of tumor thickness and depth of invasion in nodal involvement and prognosis of oral squamous cell carcinoma: A review of the literature. Head Neck, 27: 1080–1091. doi: 10.1002/hed.20275
- Issue published online: 11 NOV 2005
- Article first published online: 20 OCT 2005
- Manuscript Accepted: 16 APR 2005
- carcinoma, squamous cell;
- mouth neoplasms;
- tumor thickness;
- lymphatic metastases;
- neck dissection
Oral mucosa squamous cell carcinoma (OSCC) has locoregional evolution, with frequent neck involvement (the most important parameter for prognosis). There are still many doubts concerning the best way to approach N0 neck disease in early-stage lesions (T1 and T2). Many parameters have been studied to identify N0 patients with a high likelihood of harboring occult node metastases or of having them develop.
A review of the studies analyzing “tumor thickness”/“depth of invasion” in predicting regional metastases and survival was undertaken.
The literature suggests that “tumor thickness”/“depth of invasion” is a reliable parameter for predicting regional nodal involvement and survival in OSCC.
Authors are in substantial agreement regarding the reliability of tumor thickness. The lack of comparable study groups, measurement techniques, and cut-off values points to the need for further studies so as to reach a consensus and to develop therapy protocols that include tumor thickness. © 2005 Wiley Periodicals, Inc. Head Neck27: XXX–XXX, 2005