The first two authors have contributed equally to this article
Molecular markers of head and neck squamous cell carcinoma: Promising signs in need of prospective evaluation†
Article first published online: 11 NOV 2005
Copyright © 2005 Wiley Periodicals, Inc.
Head & Neck
Volume 28, Issue 3, pages 256–269, March 2006
How to Cite
Lothaire, P., de Azambuja, E., Dequanter, D., Lalami, Y., Sotiriou, C., Andry, G., Castro, G. and Awada, A. (2006), Molecular markers of head and neck squamous cell carcinoma: Promising signs in need of prospective evaluation. Head Neck, 28: 256–269. doi: 10.1002/hed.20326
- Issue published online: 7 FEB 2006
- Article first published online: 11 NOV 2005
- Manuscript Accepted: 21 JUL 2005
- head and neck cancer;
- molecular markers;
- proliferative markers;
- squamous cell carcinoma;
The aim of this article is to review recent developments in the biological understanding of head and neck squamous cell carcinomas.
Methods and Results.
We describe the markers according to their function and their prognostic or predictive roles. Some associations can be found between molecular markers and invasiveness, aggressiveness, degree of differentiation, and tumor stage, but only a few clinical studies have shown an impact on prognosis. In addition, despite an increasing number of articles relating to this topic, the small number of patients included in the studies reported reduces the clinical implications of these results. Few studies applied a more comprehensive molecular analysis approach, such as DNA microarrays or differential expression profiling by polymerase chain reaction, to identify a combination of markers that could be more informative than a single molecular marker.
Some progress has been made with respect to molecular markers and head and neck cancers. Translational and prospective, hypothesis-driven research must proceed with sufficient rigor to facilitate the clinical applicability of such results. © 2005 Wiley Periodicals, Inc. Head Neck27: XXX–XXX, 2005