Health-related quality of life in patients with pharyngeal carcinoma: A five-year follow-up
Article first published online: 14 NOV 2005
Copyright © 2005 Wiley Periodicals, Inc.
Head & Neck
Volume 28, Issue 4, pages 339–349, April 2006
How to Cite
Nordgren, M., Jannert, M., Boysen, M., Ahlner-Elmqvist, M., Silander, E., Bjordal, K. and Hammerlid, E. (2006), Health-related quality of life in patients with pharyngeal carcinoma: A five-year follow-up. Head Neck, 28: 339–349. doi: 10.1002/hed.20334
- Issue published online: 20 MAR 2006
- Article first published online: 14 NOV 2005
- Manuscript Accepted: 1 AUG 2005
- This study was made possible by grants from the Nordic Cancer Society (NF-43258), the Gunnar Nilsson Cancer Foundation, the Swedish Cancer Society, the Göteborg Medical Society, the King Gustav V Jubilee Clinic Cancer Research Foundation in Göteborg, the Rosa and Emanuel Nachmansson Foundation, the Assar Gabrielsson Foundation, the Maggie Stephens Foundation, the John and Augusta Persson's Foundation, the Malmö General Hospital Foundation for the treatment of Cancer and the Association for Cancer and Traffic Victims (C-24405 and C-35160)
- longitudinal HRQL;
- pharyngeal carcinoma;
- EORTC QLQ-C30;
- EORTC QLQ-H&N35;
- predictive factors
The purpose was to evaluate the health-related quality of life (HRQL) of patients with pharyngeal carcinoma at diagnosis and after 1 and 5 years in relation to tumor location and treatment modality in a prospective multicenter study.
Eighty-nine patients with pharyngeal carcinoma (mean age, 60.0 years; 76% men) were evaluated using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30) and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Head and Neck Cancer Module (EORTC QLQ-H&N35).
Problems with dry mouth and teeth became worse between diagnosis and the 5-year follow-up. Problems with thick secretions and teeth increased between 1 and 5 years. The HRQL at diagnosis was associated with survival. Patients with oropharyngeal carcinoma reported better HRQL than patients with hypopharyngeal carcinoma.
For patients with pharyngeal carcinoma, the HRQL at diagnosis seems to be an important factor for the prognosis of both HRQL over time and survival. Treatment of pharyngeal carcinoma often results in long-term side effects such as dry mouth, problems with teeth, and thick secretions. © 2005 Wiley Periodicals, Inc. Head Neck28: 339–349, 2006