Presented at the Annual Meeting of the Radiological Society of North America (RSNA), November 2004, Chicago, Illinois
Advanced-staged tonsillar squamous carcinoma: Organ preservation versus surgical management of the primary site†
Article first published online: 10 FEB 2006
Copyright © 2006 Wiley Periodicals, Inc.
Head & Neck
Volume 28, Issue 7, pages 587–594, July 2006
How to Cite
Shirazi, H. A., Sivanandan, R., Goode, R., Fee, W. E., Kaplan, M. J., Pinto, H. A., Goffinet, D. R. and Le, Q.-T. (2006), Advanced-staged tonsillar squamous carcinoma: Organ preservation versus surgical management of the primary site. Head Neck, 28: 587–594. doi: 10.1002/hed.20372
- Issue published online: 16 JUN 2006
- Article first published online: 10 FEB 2006
- Manuscript Accepted: 6 OCT 2005
- organ preservation;
- tonsillar carcinoma
Our aim was to review our experience in the management of advanced tonsillar squamous cell carcinoma (SCC) and to compare treatment outcomes between patients treated with and without surgery to the primary site.
The records of 74 patients with advanced-stage tonsillar SCC were reviewed. The median age at diagnosis was 58 years. Thirty-eight patients received definitive surgery to the primary site, and 36 were treated with an organ-preservation approach (OP) using radiotherapy ± chemotherapy.
No significant difference in overall survival (OS) or freedom from relapse (FFR) by treatment was found. T classification and N status were significant independent predictors on multivariate analysis for OS and FFR. Major late toxicity was noted in 10 patients in the surgical group and nine in the OP group.
Patients treated with OP and primary surgery had comparable OS and FFR. T classification and N status were significant independent predictors for tumor relapse and survival. On the basis of these results, we favor organ-preservation therapy for patients with advanced-stage tonsillar SCC. © 2006 Wiley Periodicals, Inc. Head Neck, 2006