Presented at the Sixth International Conference on Head and Neck Cancer in Washington DC, August 2004.
Second malignant neoplasia in early (TIS-T1) glottic carcinoma†
Article first published online: 3 MAY 2006
Copyright © 2006 Wiley Periodicals, Inc.
Head & Neck
Volume 28, Issue 6, pages 501–507, June 2006
How to Cite
Sjögren, E. V., Snijder, S., van Beekum, J. and Baatenburg de Jong, R. J. (2006), Second malignant neoplasia in early (TIS-T1) glottic carcinoma. Head Neck, 28: 501–507. doi: 10.1002/hed.20453
- Issue published online: 11 MAY 2006
- Article first published online: 3 MAY 2006
- Manuscript Accepted: 28 JUL 2005
- Comprehensive Cancer Center West, Leiden, the Netherlands
- second neoplasm;
We performed a population-based study to determine the incidence and patterns of second malignant neoplasia (SMN) in early glottic carcinoma.
All patients diagnosed with Tis-T1 glottic carcinoma in the southwest of the Netherlands between 1982 and 1993 (359) were included. Sources of the data were patient charts and the regional cancer registry.
SMN incidence was 27.7% (median follow-up, 89 months). Observed-to-expected ratios were increased for lung, bladder, urinary tract, pancreatic, colorectal, and head and neck cancers. The incidence of head and neck and esophageal cancer was surprisingly low.
Patients with early glottic carcinoma are at a reliably increased risk of the development of tumors not only in the areas of the upper aerodigestive tract, but also in the bladder, pancreas, and colorectum. The low incidence of head and neck and esophageal tumors does not appear to support routine panendoscopy in this patient population. © 2006 Wiley Periodicals, Inc. Head Neck 28:501–507, 2006