Phase II analysis of paclitaxel and capecitabine in the treatment of recurrent or disseminated squamous cell carcinoma of the head and neck region
Article first published online: 13 NOV 2006
Copyright © 2006 Wiley Periodicals, Inc.
Head & Neck
Volume 29, Issue 1, pages 47–51, January 2007
How to Cite
Bentzen, J. D. and Hansen, H. S. (2007), Phase II analysis of paclitaxel and capecitabine in the treatment of recurrent or disseminated squamous cell carcinoma of the head and neck region. Head Neck, 29: 47–51. doi: 10.1002/hed.20462
- Issue published online: 8 DEC 2006
- Article first published online: 13 NOV 2006
- Manuscript Accepted: 12 APR 2006
- head and neck cancer;
- squamous cell carcinoma;
The aim of this phase II study was to evaluate the antitumor activity and toxicity of a non-platin–containing regimen with paclitaxel and capecitabine.
Fifty patients with recurrent or disseminated squamous cell carcinoma were included in the study. The treatment consisted of paclitaxel 175 mg/m2 once every third week and capecitabine 825 mg/m2 per oral (p.o.) twice daily (bid) for 2 weeks.
The overall response rate according to the World Health Organization (WHO) criteria was 42%. Two patients had a complete response (CR), 19 patients had a partial response (PR), 14 patients had no change (NC), 12 patients had progressive disease (PD), and 3 patients were not evaluable (NE). The median survival time was 8 months. Toxicity was very moderate. Only 10% of 315 delivered treatments had to be given in reduced dose or postponed for a week or more.
The toxicity was low and manageable. The overall response rate was comparable to the commonly used cisplatin/5-fluorouracil regimen. © 2006 Wiley Periodicals, Inc. Head Neck 2007