Role of mitomycin in upper digestive tract stricture
Article first published online: 4 OCT 2006
Copyright © 2006 Wiley Periodicals, Inc.
Head & Neck
Volume 29, Issue 1, pages 12–17, January 2007
How to Cite
Gillespie, M. B., Day, T. A., Sharma, A. K., Brodsky, M. B. and Martin-Harris, B. (2007), Role of mitomycin in upper digestive tract stricture. Head Neck, 29: 12–17. doi: 10.1002/hed.20476
- Issue published online: 8 DEC 2006
- Article first published online: 4 OCT 2006
- Manuscript Accepted: 1 MAY 2006
- mitomycin C;
- esophageal stricture;
- esophageal stenosis;
- head and neck cancer
Mitomycin C is an anti-fibroblast chemotherapeutic agent that has demonstrated promise in the treatment of head and neck cancer-related cervical stenosis. The present study investigates whether the application of mitomycin C at the time of dilation is both safe and effective in the treatment of head and neck cancer-related upper digestive tract stricture.
Twelve patients with progressive dysphagia and videofluroscopic evidence of upper digestive tract stricture after head and neck cancer treatment were dilated by Maloney or Savory dilators followed by the application of mitomycin C (0.2 mg/0.4 mL saline) to the stenotic segment for 5 minutes. Outcome measures included complication rate, improvement in baseline dietary consistency, and improvement in swallowing-related quality of life as measured by the M. D. Anderson Dysphagia Inventory.
All patients experienced improvement in their baseline dietary consistency (p = .002) and M. D. Anderson Dysphagia Inventory composite score (p = .001) after a mean follow-up time of 19 months. No complications from mitomycin use were observed.
Mitomycin application appears to be a safe and potentially effective treatment for head and neck cancer-related upper digestive tract stricture. Given the small sample size and limited follow-up time, a randomized, controlled trial is needed to determine whether mitomycin application offers additional benefit over standard dilation therapy. © 2006 Wiley Periodicals, Inc. Head Neck, 2006