Histologic characteristics and tumor spread of recurrent glottic carcinoma: Analysis on whole-organ sections and comparison with tumor spread of primary glottic carcinomas
Article first published online: 13 NOV 2006
Copyright © 2006 Wiley Periodicals, Inc.
Head & Neck
Volume 29, Issue 1, pages 26–32, January 2007
How to Cite
Zbären, P., Nuyens, M., Curschmann, J. and Stauffer, E. (2007), Histologic characteristics and tumor spread of recurrent glottic carcinoma: Analysis on whole-organ sections and comparison with tumor spread of primary glottic carcinomas. Head Neck, 29: 26–32. doi: 10.1002/hed.20502
- Issue published online: 8 DEC 2006
- Article first published online: 13 NOV 2006
- Manuscript Accepted: 24 APR 2006
- glottic carcinoma;
- irradiation failure;
- tumor spread;
- voice-preserving surgery
The assessment of the precise tumor extent of recurrent glottic carcinomas is a challenge.
The histologic characteristics of 29 recurrent glottic carcinomas after radiation failures, initially classified as T1 and T2, were analyzed on whole-organ slices. The growth patterns of 21 recurrent prT3 and prT4 and 52 primary pT3 and pT4 carcinomas were compared.
Fifteen of 29 (52%) recurrent carcinomas were understaged by imaging studies and endoscopy. Most recurrent carcinomas presented with multicentric tumor foci, whereas most primary carcinomas with a concentric tumor growth pattern (p < .05). Undifferentiated dissociated tumor cells were observed more often in the vicinity of recurrent tumor foci than of the primary tumor mass (p < .05).
Recurrent glottic carcinomas are often understaged and present with multiple tumor foci dispersed in different regions of the larynx. If voice-preserving salvage surgery is considered as a treatment option, these facts should be kept in mind. © 2006 Wiley Periodicals, Inc. Head Neck 2007