Quality of life in oral carcinoma: A 5-year prospective study
Article first published online: 20 DEC 2007
Copyright © 2007 Wiley Periodicals, Inc.
Head & Neck
Volume 30, Issue 4, pages 461–470, April 2008
How to Cite
Nordgren, M., Hammerlid, E., Bjordal, K., Ahlner-Elmqvist, M., Boysen, M. and Jannert, M. (2008), Quality of life in oral carcinoma: A 5-year prospective study. Head Neck, 30: 461–470. doi: 10.1002/hed.20735
- Issue published online: 14 MAR 2008
- Article first published online: 20 DEC 2007
- Manuscript Accepted: 4 JUL 2007
- Nordic Cancer Society. Grant Number: NF-43258
- Association for Cancer and Traffic Victims. Grant Numbers: C-24405, C-35160
- Gunnar Nilsson Cancer Foundation
- Swedish Cancer Society
- Göteborg Medical Society
- King Gustav V Jubilee Clinic Cancer Research Foundation in Göteborg
- Rosa and Emanuel Nachmansson Foundation
- Assar Gabrielsson Foundation
- Maggie Stephens Foundation
- John and Augusta Persson's Foundation
- Malmö General Hospital Foundation for the treatment of Cancer
- longitudinal HRQL;
- oral carcinoma;
- EORTC QLQ-C30;
- EORTC QLQ-H&N35;
- predictive factors
We conducted this prospective longitudinal multicenter study to evaluate the health-related quality of life (HRQL) of patients with oral carcinoma at diagnosis, and after 1 and 5 years in relation to tumour location and treatment modality.
One hundred twenty-two patients (mean age, 61; 62% males) with oral carcinoma were evaluated with standardized HRQL questionnaires, the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core30 (EORTC QLQ-C30) and the EORTC Head and Neck Cancer Module (EORTC QLQ-H&N35).
Problems with teeth, dry mouth, and sticky saliva got worse between diagnosis and 5 years after diagnosis. Problems with dry mouth remained a problem between 1 and 5 years after diagnosis, except for the patients treated with surgery only. This group had fewer problems over time compared with patients receiving other treatment regimes. Survivors reported better HRQL than the nonsurvivors at diagnosis and at the 1-year follow-up. HRQL at diagnosis was associated with survival.
HRQL at diagnosis for patients with oral carcinoma seems to be an important factor for the prognosis of both HRQL over time and survival. Treatment of oral carcinoma often results in long-term side effects such as dry mouth, problems with teeth, and sticky saliva. © 2007 Wiley Periodicals, Inc. Head Neck, 2008