Pilot study: Volatile organic compounds as a diagnostic marker for head and neck tumors
Article first published online: 19 FEB 2008
Copyright © 2008 Wiley Periodicals, Inc.
Head & Neck
Volume 30, Issue 6, pages 743–749, June 2008
How to Cite
Schmutzhard, J., Rieder, J., Deibl, M., Schwentner, I. M., Schmid, S., Lirk, P., Abraham, I. and Gunkel, A. R. (2008), Pilot study: Volatile organic compounds as a diagnostic marker for head and neck tumors. Head Neck, 30: 743–749. doi: 10.1002/hed.20779
- Issue published online: 13 MAY 2008
- Article first published online: 19 FEB 2008
- Manuscript Accepted: 25 SEP 2007
- The Austrian Science Fund (FWF). Grant Number: P-14149MED
- The Innovationspreis der Tiroler Sparkasse and the Daniel Swarovski research award of the Medical Faculty, University of Innsbruck
- proton transfer reaction-mass spectrometry;
- screening method;
In the last decade, the analysis of volatile organic compounds (VOC) has undergone a rapid development. In this pilot study, patients with HNSCC were tested with a proton transfer reaction-mass spectrometry in order to establish a minimal invasive screening method.
Overall in a period of 2 years, 22 carcinoma patients were recruited for the study. All patients had a newly diagnosed histologically secured squamous cell carcinoma of the upper aerodigestive tract. These results were statistically compared with 3 control groups: healthy controls, high-risk, and posttherapy patients.
Two hundred nine different masses were measured; 188 of these were evaluated. The statistical workup of the 4 study groups produced 42 different masses, which showed a statistically significant difference from the carcinoma group compared with the control groups.
A screening method for HNSCC using VOC seems to be possible, but further investigation is necessary. © 2008 Wiley Periodicals, Inc. Head Neck, 2008