Parts of this work were presented at the following conferences and received awards: 2007 Multidisciplinary Head & Neck Cancer Symposium Rancho Mirage, CA (ASTRO Travel Grant); 2007 New York Roentgen Society Meeting (1st prize).
Postoperative intensity-modulated radiation therapy for cancers of the paranasal sinuses, nasal cavity, and lacrimal glands: Technique, early outcomes, and toxicity†
Article first published online: 26 FEB 2008
Copyright © 2008 Wiley Periodicals, Inc.
Head & Neck
Volume 30, Issue 7, pages 925–932, July 2008
How to Cite
Hoppe, B. S., Wolden, S. L., Zelefsky, M. J., Mechalakos, J. G., Shah, J. P., Kraus, D. H. and Lee, N. (2008), Postoperative intensity-modulated radiation therapy for cancers of the paranasal sinuses, nasal cavity, and lacrimal glands: Technique, early outcomes, and toxicity. Head Neck, 30: 925–932. doi: 10.1002/hed.20800
- Issue published online: 9 JUN 2008
- Article first published online: 26 FEB 2008
- Manuscript Accepted: 9 NOV 2007
- paranasal sinus;
- lacrimal gland;
- nasal cavity;
Our aim was to review Memorial Sloan-Kettering Cancer Center's experience with postoperative intensity-modulated radiotherapy (IMRT) for paranasal sinus, nasal cavity, and lacrimal gland cancer and report dosimetric measures, toxicity, and outcomes.
Between September 2000 and June 2006, 37 patients with paranasal sinus, nasal cavity, or lacrimal gland cancer underwent postoperative IMRT. Median values were as follows: prescription dose, 60 Gy (range, 50–70); PTVD95, 99% (range, 79–101%); optic nerve Dmax, 53 Gy (range, 2–54); optic chiasm Dmax, 51Gy (range, 2–55). Acute and late toxicities were scored by Radiation Therapy Oncology Group morbidity criteria.
Median follow-up was 28 months. Two-year local progression–free and overall survivals were 75% and 80%. No early- or late-grade 3/4 radiation-induced ophthalmologic toxicity occurred.
Preliminary results show that adjuvant IMRT in these patients is feasible, allowed for excellent planning target volume (PTV) coverage, and minimized dose delivered to optic structures. Longer follow-up is warranted to assess the extent of late effects and outcomes. © 2008 Wiley Periodicals, Inc. Head Neck, 2008