Laryngeal true malignant mixed tumor
Article first published online: 28 OCT 2008
Copyright © 2008 Wiley Periodicals, Inc.
Head & Neck
Volume 31, Issue 4, pages 556–560, April 2009
How to Cite
Stomeo, F., Rocca, P. C., Bozzo, C., Bianchini, C., Meloni, F., Pastore, A. (2009), Laryngeal true malignant mixed tumor. Head Neck, 31: 556–560. doi: 10.1002/hed.20939
- Issue published online: 11 MAR 2009
- Article first published online: 28 OCT 2008
- Manuscript Accepted: 5 JUN 2008
- mixed tumor;
- salivary glands tumors
True malignant mixed tumor, also known as carcinosarcoma, is a salivary gland type malignant neoplasm, which is extremely rare, and only a few cases arising in the larynx have been previously reported.
Methods and Results.
We report a case of true malignant mixed tumor arising in the larynx of a 65-year-old woman successfully treated with surgery. Histologically, the neoplasm was composed of variably mixed, neoplastic glandular, spindle, and chondroid tissues. Immunohistochemical analyses showed a peculiar expression of myoepithelial markers such as p63 and calponin in the glandular epithelial component, whereas malignant spindle cell proliferation was immunoreactive for calponin and actin.
These results strengthen the hypothesis that these neoplasms may develop from a divergent differentiation of a totipotent, myoepithelial precursor cell. Despite the unfavorable prognosis that has always been described for these neoplasms, the patient is alive with no evidence of recurrences 5 years after surgery. © 2008 Wiley Periodicals, Inc. Head Neck, 2009