Brachytherapy boost for T1/T2 nasopharyngeal carcinoma
Article first published online: 17 JUN 2009
Copyright © 2009 Wiley Periodicals, Inc.
Head & Neck
Volume 31, Issue 12, pages 1610–1618, December 2009
How to Cite
Yeo, R., Fong, K. W., Hee, S. W., Chua, E. T., Tan, T. and Wee, J. (2009), Brachytherapy boost for T1/T2 nasopharyngeal carcinoma. Head Neck, 31: 1610–1618. doi: 10.1002/hed.21130
- Issue published online: 9 NOV 2009
- Article first published online: 17 JUN 2009
- Manuscript Accepted: 18 FEB 2009
- Manuscript Revised: 4 FEB 2009
- Manuscript Received: 11 OCT 2008
- nasopharyngeal carcinoma;
- local control
The aim of this study was to review our experience and demonstrate the safety of intracavitary brachytherapy (ICB) in patients with nasopharyngeal carcinoma (NPC).
Hundred seventy-eight patients with early T1-2b disease underwent radical external beam radiation therapy (EBRT) followed by ICB boost. The primary tumor received 66 Gy of EBRT over 33 fractions using 6 or 10 MV photons. ICB insertions were performed 1 week later, delivering 10 Gy in 2 fractions over 8 days. Kaplan-Meier survival analyses were used to calculate the actuarial 5-year overall survival (OS), cause-specific survival, local control, and disease-free survival (DFS).
Five-year local control rates were 91.6%. OS, DFS, and cause-specific survival were estimated to be 85.25%, 81.7%, and 87.9%, respectively. Median follow-up was 86 months. There were no documented serious complications noted with ICB.
ICB boost supplementing radical EBRT is an excellent method of enhancing local control for patients with NPC with early T1-2b disease. © 2009 Wiley Periodicals, Inc. Head Neck, 2009