Three synchronous HPV-associated squamous cell carcinomas of Waldeyer's ring: Case report and comparison with Slaughter's model of field cancerization
Version of Record online: 1 JUL 2009
Copyright © 2009 Wiley Periodicals, Inc.
Head & Neck
Volume 32, Issue 8, pages 1118–1124, August 2010
How to Cite
McGovern, S. L., Williams, M. D., Weber, R. S., Sabichi, A., Chambers, M. S., Martin, J. W., Chao, K. S. C. (2010), Three synchronous HPV-associated squamous cell carcinomas of Waldeyer's ring: Case report and comparison with Slaughter's model of field cancerization. Head Neck, 32: 1118–1124. doi: 10.1002/hed.21171
- Issue online: 13 JUL 2010
- Version of Record online: 1 JUL 2009
- Manuscript Accepted: 17 APR 2009
- squamous cell carcinoma;
- Waldeyer's ring;
Patients with squamous cell carcinoma (SCC) of the oropharynx have an 8% to 20% risk of a synchronous or metachronous second malignancy. The rate of synchronous lesions in human papillomavirus (HPV)-positive oropharyngeal cancers is unknown.
We report the case of a 46-year-old man with 3 simultaneous primary malignancies of Waldeyer's ring: HPV-positive SCC of both tonsils and the nasopharynx, with bilateral neck metastases.
The patient received induction chemotherapy followed by definitive radiotherapy and remains free of disease at 18 months.
Comparison with the Slaughter model of field cancerization suggests that HPV-positive SCC of the head and neck may have a distinct mechanism for the development of multifocal disease. Therefore, the emerging population of young patients with head and neck SCC with HPV-positive cancers presents a new opportunity for understanding the molecular origins of synchronous tumors. © 2009 Wiley Periodicals, Inc. Head Neck, 2009