The authors Jay Stoerker, Heather Walline, and Thomas E. Carey have a conflict of interest. Jay Stoerker and Heather Walline are employed with the Sequenom Center for Molecular Medicine; Thomas E. Carey serves as the member of the Sequenom Clinical Advisory Board and presented some of the work to a group of Sequenom officials and other researchers and received a honorarium of $1000 and reimbursement for travel.
HPV-positive/p16-positive/EBV-negative nasopharyngeal carcinoma in white North Americans†
Article first published online: 15 SEP 2009
Copyright © 2009 Wiley Periodicals, Inc.
Head & Neck
Volume 32, Issue 5, pages 562–567, May 2010
How to Cite
Maxwell, J. H., Kumar, B., Feng, F. Y., McHugh, J. B., Cordell, K. G., Eisbruch, A., Worden, F. P., Wolf, G. T., Prince, M. E., Moyer, J. S., Teknos, T. N., Chepeha, D. B., Stoerker, J., Walline, H., Carey, T. E. and Bradford, C. R. (2010), HPV-positive/p16-positive/EBV-negative nasopharyngeal carcinoma in white North Americans. Head Neck, 32: 562–567. doi: 10.1002/hed.21216
- Issue published online: 8 APR 2010
- Article first published online: 15 SEP 2009
- Manuscript Accepted: 17 JUN 2009
- Manuscript Revised: 13 MAY 2009
- Manuscript Received: 22 JAN 2009
- National Institutes of Health (NIH) NIDCR. Grant Number: R01 DE13346
- NIH NIDCD. Grant Number: P30 DC 05188
- NIH National Cancer Institute. Grant Number: R01 CA83087
- NIH-NCI NIDCR. Grant Number: P50 CA97248
- NCI National Cancer Center. Grant Numbers: P30 CA46592, MEDC-410
- nasopharyngeal carcinoma;
- human papillomavirus;
- Epstein-Barr virus;
- white North Americans
Human papillomavirus (HPV) has been detected in keratinizing nasopharyngeal carcinomas (NPCs); however, the relationship between HPV and Epstein–Barr virus (EBV) among whites with nonkeratinizing NPCs remains unclear. The HPV, p16, and EBV status was examined in current University of Michigan patients with NPC.
From 2003 to 2007, 89 patients, 84 with oropharyngeal cancer (OPC) and 5 with NPC, were enrolled in an organ-sparing trial. Biopsy tissues from all 89 patients were evaluated for HPV and p16 expression. A separate HPV analysis of the 84 OPC patients is in progress. Among the patients with NPC, tumor tissue was also analyzed for EBV-encoded RNA (EBER).
Five of 89 patients (5.6%) had NPC, all with nonkeratinizing histology. The 4 white patients with NPC were HPV(+) (subtype-16, subtype-18 [2 patients], and subtype-59)/p16(+)/EBER(-). One Asian patient with NPC had an HPV(-)/p16(-)/EBER(+) NPC tumor that developed distant metastases.
We postulate that HPV may be the etiologic factor in some EBV-negative, nonkeratinizing NPCs among whites. © 2009 Wiley Periodicals, Inc. Head Neck, 2010