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Keywords:

  • MMP;
  • matrix metalloproteinase;
  • Ki-67;
  • HER-2;
  • salivary gland cancer;
  • epithelial-myoepithelial carcinoma

Abstract

Background

The expression of matrix metalloproteinases (MMPs) in epithelial-myoepithelial salivary gland carcinoma has not been studied previously.

Methods

Immunohistochemistry for MMP-1, -7, -9, -13, Ki-67, and HER-2, as well as HER-2 gene amplification by silver enhanced in situ hybridization was performed in a series of 12 paraffin-embedded histopathologic samples of patients from Canada and Finland.

Results

A positive MMP-13 (p = .0022), higher MMP-13 (p = .0274), and higher MMP-9 (p = .0274) index (multiplication of staining intensity by percentage of the positive cells) predicted better overall survival. In disease-specific analysis, higher MMP-9 index (p = .0327) predicted better survival. A higher volume corrected index (VCI) of Ki-67 (p = .0339) predicted worse disease-specific survival. In 1 patient, HER-2 oncogene amplification was observed.

Conclusion

MMPs and Ki-67 may have prognostic impact in epithelial-myoepithelial carcinoma. © 2009 Wiley Periodicals, Inc. Head Neck, 2010