Glutathione S-transferase P1 and alpha gene variants; role in susceptibility and tumor size development of oral cancer

Authors

  • Mu-Kuan Chen MD, PhD,

    1. Department of Otorhinolaryngology–Head and Neck Surgery, Changhua Christian Hospital, Changhua, Taiwan
    2. Mingdao University, Changhua, Taiwan
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    • The first 2 authors contributed equally to this work.

  • Hsiu-Ting Tsai PhD,

    1. School of Nursing, College of Nursing, Chung Shan Medical University, Taichung, Taiwan
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    • The first 2 authors contributed equally to this work.

  • Tsung-Te Chung MD,

    1. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
    2. Department of Otolaryngology, Show Chwan Memorial Hospital, Changhua, Taiwan
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  • Shih-Chi Su MS,

    1. Department of Molecular and Cellular Medicine, Texas A&M University System Health Science Center, College Station, Texas
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  • Te-Yu Kao MS,

    1. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
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  • Hsien-Chun Tseng MD, PhD,

    1. Department of Radiation Oncology, Chung Shan Medical University Hospital, Taichung, Taiwan
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  • Te-Hsiung Liu MD,

    1. Department of Otolaryngology, Show Chwan Memorial Hospital, Changhua, Taiwan
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  • Hui-Ling Chiou PhD,

    Corresponding author
    1. School of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, Taiwan
    2. Department of Clinical Laboratory, Chung Shan Medical University Hospital, Taichung, Taiwan
    • School of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, Taiwan
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  • Shun-Fa Yang PhD

    Corresponding author
    1. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
    2. Department of Clinical Laboratory, Chung Shan Medical University Hospital, Taichung, Taiwan
    3. Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan
    • Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
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Abstract

Background.

The aim of this study was to estimate the relationship of glutathione S-transferases (GST)P1, GSTA1, GSTM1, and GSTT1 gene polymorphisms to oral cancer risk.

Methods.

Polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) was used to measure these 4 gene polymorphisms in 274 controls and 164 oral cancer patients.

Results.

Individuals with at least 1 varied G allele of GSTP1 had a 1.53-fold risk (95% confidence interval [CI] = 1.01–2.31) of developing oral cancer compared with patients with wild-type A/A homozygotes. Oral cancer patients with at least 1 varied T allele of GSTA1 gene had a 0.42-fold risk (95% CI = 0.18–0.95) of having a tumor size >2 cm compared with patients with C/C homozygotes.

Conclusions.

The varied G allele of GSTP1 may be considered as a factor contributing to increased susceptibility, whereas the T allele of GSTA1 could be a protective factor for tumor size progression in Taiwanese with oral cancer. © 2009 Wiley Periodicals, Inc. Head Neck, 2010

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