The first 2 authors contributed equally to this work.
Glutathione S-transferase P1 and alpha gene variants; role in susceptibility and tumor size development of oral cancer
Article first published online: 1 DEC 2009
Copyright © 2009 Wiley Periodicals, Inc.
Head & Neck
Volume 32, Issue 8, pages 1079–1087, August 2010
How to Cite
Chen, M.-K., Tsai, H.-T., Chung, T.-T., Su, S.-C., Kao, T.-Y., Tseng, H.-C., Liu, T.-H., Chiou, H.-L. and Yang, S.-F. (2010), Glutathione S-transferase P1 and alpha gene variants; role in susceptibility and tumor size development of oral cancer. Head Neck, 32: 1079–1087. doi: 10.1002/hed.21297
- Issue published online: 13 JUL 2010
- Article first published online: 1 DEC 2009
- Manuscript Accepted: 14 SEP 2009
- Manuscript Revised: 11 JUL 2009
- Manuscript Received: 24 MAR 2009
- National Science Council, Taiwan. Grant Number: NSC97-2314-B-040-025-MY3
- oral cancer
The aim of this study was to estimate the relationship of glutathione S-transferases (GST)P1, GSTA1, GSTM1, and GSTT1 gene polymorphisms to oral cancer risk.
Polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) was used to measure these 4 gene polymorphisms in 274 controls and 164 oral cancer patients.
Individuals with at least 1 varied G allele of GSTP1 had a 1.53-fold risk (95% confidence interval [CI] = 1.01–2.31) of developing oral cancer compared with patients with wild-type A/A homozygotes. Oral cancer patients with at least 1 varied T allele of GSTA1 gene had a 0.42-fold risk (95% CI = 0.18–0.95) of having a tumor size >2 cm compared with patients with C/C homozygotes.
The varied G allele of GSTP1 may be considered as a factor contributing to increased susceptibility, whereas the T allele of GSTA1 could be a protective factor for tumor size progression in Taiwanese with oral cancer. © 2009 Wiley Periodicals, Inc. Head Neck, 2010