This study was presented at the 33rd Annual Meeting of the Japan Society for Head and Neck Cancer, Hokkaido, Japan, June 10–12, 2009.
Tumor-induced osteomalacia originating from the temporal bone: A case report†
Version of Record online: 9 FEB 2010
Copyright © 2010 Wiley Periodicals, Inc.
Head & Neck
Volume 33, Issue 7, pages 1072–1075, July 2011
How to Cite
Kobayashi, K., Nakao, K., Kawai, K., Ito, K., Hukumoto, S., Asakage, T., Oota, S., Motoi, R. (2011), Tumor-induced osteomalacia originating from the temporal bone: A case report. Head Neck, 33: 1072–1075. doi: 10.1002/hed.21355
- Issue online: 9 FEB 2010
- Version of Record online: 9 FEB 2010
- Manuscript Accepted: 20 NOV 2009
- Manuscript Received: 21 OCT 2009
- temporal bone;
- skull base surgery;
- embolization of tumor
Tumor-induced osteomalacia (TIO) is a rare clinical entity in which secondary osteomalacia is induced by tumor-related products. Fibroblast growth factor 23 (FGF-23) mRNA is overexpressed in the tumor tissue, leading to impaired reabsorption of phosphorus in the renal tubules and hypophosphatemia. Curative treatment is considered to be total resection of the tumor.
Methods and Results.
A 53-year-old woman had experienced systemic bone pain and muscle weakness for several years. She had refractory hypophosphatemia and marked elevation of serum FGF-23 level. Whole body imaging eventually revealed a hypervascular mass in the right temporal bone, leading to a diagnosis of TIO. She underwent skull-base surgery after embolization of the tumor. After the en bloc resection, FGF-23 became undetectable, phosphate reabsorption normalized, and all symptoms resolved.
We discuss the clinical features and treatment options for this rare disease. © 2010 Wiley Periodicals, Inc. Head Neck, 2011