Submandibular salivary gland transfer for the prevention of radiation-induced xerostomia in patients with nasopharyngeal carcinoma: 5-Year outcomes

Authors

  • Xue-Kui Liu MD, PhD,

    1. State Key Laboratory of Oncology in South China, Department of Head and Neck Surgery, Cancer Centre, Sun Yat-Sen University, Guangzhou, Guangdon, P.R. China
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  • Yong Su MD, PhD,

    1. State Key Laboratory of Oncology in South China, Department of Radiation Therapy, Cancer Centre, Sun Yat-Sen University, Guangzhou, Guangdon, P.R. China
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  • Naresh Jha MBBS,

    1. Department of Radiation Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada
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  • Ming-Huan Hong MD,

    1. State Key Laboratory of Oncology in South China, Department of Nasopharyngeal Carcinoma, Cancer Centre, Sun Yat-Sen University, Guangzhou, Guangdon, P.R. China
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  • Hai-Qiang Mai MD, PhD,

    1. State Key Laboratory of Oncology in South China, Department of Nasopharyngeal Carcinoma, Cancer Centre, Sun Yat-Sen University, Guangzhou, Guangdon, P.R. China
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  • Wei Fan MD, PhD,

    1. State Key Laboratory of Oncology in South China, Department of Nuclear Medicine, Cancer Centre, Sun Yat-Sen, University, Guangzhou, Guangdon, P.R. China
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  • Zong-Yuan Zeng MD,

    1. State Key Laboratory of Oncology in South China, Department of Head and Neck Surgery, Cancer Centre, Sun Yat-Sen University, Guangzhou, Guangdon, P.R. China
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  • Zhu-Ming Guo MD

    Corresponding author
    1. State Key Laboratory of Oncology in South China, Department of Head and Neck Surgery, Cancer Centre, Sun Yat-Sen University, Guangzhou, Guangdon, P.R. China
    • State Key Laboratory of Oncology in South China, Department of Head and Neck Surgery, Cancer Centre, Sun Yat-Sen University, Guangzhou, Guangdon, P.R. China
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Abstract

Background

Our aim in this study was to investigate the value of the submandibular salivary gland transfer procedure in prevention of radiation-induced xerostomia in patients with nasopharyngeal carcinoma (NPC).

Methods

In all, there were 70 patients, consisting of a test group (36 patients) and a control group (34 patients) in a nonrandomized fashion. In the test group, the submandibular salivary gland was transferred to submental space before radiotherapy (XRT) and shielded. Salivary gland functions were evaluated by the amount of saliva and a quality of life questionnaire before and after XRT and 3 and 60 months after XRT.

Results

At 5 years, the trapping and excretion functions of salivary gland were significantly better in the test group (p = .000 and p = .000). The mean weight of saliva after XRT was heavier (1.65 g vs 0.73 g, p = .000), and the incidence of xerostomia was lower in the test group, with no difference in 5-year survival and neck nodal recurrence between the 2 groups.

Conclusions

Salivary gland transfer procedure prevents XRT-induced xerostomia and improves quality of life of patients with NPC. © 2010 Wiley Periodicals, Inc. Head Neck, 2010

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