The first 2 authors contributed equally to this work.
Serum decoy receptor 3 level: A predictive marker for nodal metastasis and survival among oral cavity cancer patients
Article first published online: 19 JUL 2010
Copyright © 2010 Wiley Periodicals, Inc.
Head & Neck
Volume 33, Issue 3, pages 396–402, March 2011
How to Cite
Tu, H.-F., Liu, C.-J., Liu, S.-Y., Chen, Y.-P., Yu, E.-H., Lin, S.-C. and Chang, K.-W. (2011), Serum decoy receptor 3 level: A predictive marker for nodal metastasis and survival among oral cavity cancer patients. Head Neck, 33: 396–402. doi: 10.1002/hed.21467
- Issue published online: 11 FEB 2011
- Article first published online: 19 JUL 2010
- Manuscript Accepted: 30 MAR 2010
- Manuscript Revised: 25 DEC 2009
- Manuscript Received: 6 SEP 2009
- National Science Council. Grant Number: NSC-96-2628-B-010-010-MY3
- Chi-Yang. Grant Number: CM-YM 95-01
- National Yang-Ming University Hospital. Grant Number: RD2009-006
- gene copy number;
- oral cavity;
Validating markers for prediction of nodal metastasis could be beneficial in treatment of oral cavity cancer. Decoy receptor 3 (DcR3), locus on 20q13, functions as a death decoy inhibiting apoptosis mediated by the tumor necrosis factor receptor (TNFR) family.
This study analyzed the serum level of DcR3 in relationship to the clinical parameters of oral cavity cancer patients together with detection of DcR3 genomic copy number in primary and recurrent tumors.
Elevated serum DcR3 was associated with nodal metastasis and worse prognosis. Gain of DcR3 copy number was detected in 17% of primary tumor tissue but not found in healthy areca chewers. Tissue from recurrent tumors showed more frequent DcR3 copy number alteration (48%) than the paired primary tumor tissue.
Serum DcR3 level is a predictor for the nodal metastasis and survival among oral cavity cancer patients and the DcR3 copy number alteration could underlie oral carcinogenesis progression. © 2010 Wiley Periodicals, Inc. Head Neck, 2010