Serum decoy receptor 3 level: A predictive marker for nodal metastasis and survival among oral cavity cancer patients

Authors

  • Hsi-Feng Tu DDS, MS,

    1. Institute of Oral Biology, School of Dentistry, National Yang-Ming University, Taipei, Taiwan
    2. Department of Dentistry, National Yang-Ming University Hospital, I-Lan, Taiwan
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    • The first 2 authors contributed equally to this work.

  • Chung-Ji Liu DDS, MS,

    1. Institute of Oral Biology, School of Dentistry, National Yang-Ming University, Taipei, Taiwan
    2. Department of Oral and Maxillofacial Surgery, Taipei Mackay Memorial Hospital, Taipei, Taiwan
    3. MacKay Medicine, Nursing and Management College, Taipei, Taiwan
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    • The first 2 authors contributed equally to this work.

  • Shyun-Yeu Liu DDS,

    1. Department of Oral and Maxillofacial Surgery, Chi-Mei Medical Center, Tainan, Taiwan
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  • Yu-Ping Chen MS,

    1. Institute of Oral Biology, School of Dentistry, National Yang-Ming University, Taipei, Taiwan
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  • En-Hao Yu DDS,

    1. Department of Dentistry, National Yang-Ming University Hospital, I-Lan, Taiwan
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  • Shu-Chun Lin PhD,

    Corresponding author
    1. Institute of Oral Biology, School of Dentistry, National Yang-Ming University, Taipei, Taiwan
    • Institute of Oral Biology, School of Dentistry, National Yang-Ming University, Taipei, Taiwan
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  • Kuo-Wei Chang DDS, PhD

    Corresponding author
    1. Institute of Oral Biology, School of Dentistry, National Yang-Ming University, Taipei, Taiwan
    2. Department of Dentistry, Veterans General Hospital, Taipei, Taiwan
    3. Department of Medical Education and Research, Veterans General Hospital, Taipei, Taiwan
    • Institute of Oral Biology, School of Dentistry, National Yang-Ming University, Taipei, Taiwan
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Abstract

Background.

Validating markers for prediction of nodal metastasis could be beneficial in treatment of oral cavity cancer. Decoy receptor 3 (DcR3), locus on 20q13, functions as a death decoy inhibiting apoptosis mediated by the tumor necrosis factor receptor (TNFR) family.

Methods.

This study analyzed the serum level of DcR3 in relationship to the clinical parameters of oral cavity cancer patients together with detection of DcR3 genomic copy number in primary and recurrent tumors.

Results.

Elevated serum DcR3 was associated with nodal metastasis and worse prognosis. Gain of DcR3 copy number was detected in 17% of primary tumor tissue but not found in healthy areca chewers. Tissue from recurrent tumors showed more frequent DcR3 copy number alteration (48%) than the paired primary tumor tissue.

Conclusions.

Serum DcR3 level is a predictor for the nodal metastasis and survival among oral cavity cancer patients and the DcR3 copy number alteration could underlie oral carcinogenesis progression. © 2010 Wiley Periodicals, Inc. Head Neck, 2010

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