Prognostic impact of different TNM-based stage groupings for oral squamous cell carcinoma
Article first published online: 29 NOV 2010
Copyright © 2010 Wiley Periodicals, Inc.
Head & Neck
Volume 33, Issue 10, pages 1467–1475, October 2011
How to Cite
Kreppel, M., Drebber, U., Rothamel, D., Eich, H.-T., Kübler, A., Scheer, M. and Zöller, J. E. (2011), Prognostic impact of different TNM-based stage groupings for oral squamous cell carcinoma. Head Neck, 33: 1467–1475. doi: 10.1002/hed.21630
- Issue published online: 16 SEP 2011
- Article first published online: 29 NOV 2010
- Manuscript Accepted: 31 AUG 2010
- oral cancer;
- stage grouping;
- multivariate analysis
The purpose of this study was to evaluate the prognostic significance of different TNM-based stage groupings proposed in the literature.
We conducted a retrospective analysis of 300 patients with primary oral squamous cell carcinoma (T1–4, N0–2, M0). The stage grouping systems of the sixth edition of the Union Internationale Contre le Cancer (UICC), T and N Integer Score (TANIS), the Snyderman scheme, the Hart scheme, and the Berg scheme were tested for their prognostic significance. Disease free survival (DFS) was plotted by Kaplan–Meier analysis. Prognostic factors were identified through univariate and multivariate analysis.
On univariate analysis, all systems revealed discriminatory power for DFS; however, on multivariate analysis, only the Hart scheme predicted DFS. The TANIS did not have a better prognostic ability than the UICC stage grouping.
Unlike in previous studies, the UICC stage grouping did perform worse than other TNM-based stage groupings, which may be due to the alterations made in the sixth edition. © 2010 Wiley Periodicals, Inc. Head Neck, 2010