This work was presented at the Poster Session of the Combined Otolaryngology Spring Meeting (COSM), April 28–29, 2010, Las Vegas, Nevada.
Factors associated with pharyngoesophageal stricture in patients treated with concurrent chemotherapy and radiation therapy for oropharyngeal squamous cell carcinoma†
Article first published online: 18 JAN 2011
Copyright © 2011 Wiley Periodicals, Inc.
Head & Neck
Volume 33, Issue 12, pages 1727–1734, December 2011
How to Cite
Best, S. R., Ha, P. K., Blanco, R. G., Saunders, J. R., Zinreich, E. S., Levine, M. A., Pai, S. I., Walker, M., Trachta, J., Ulmer, K., Murakami, P., Thompson, R., Califano, J. A. and Messing, B. P. (2011), Factors associated with pharyngoesophageal stricture in patients treated with concurrent chemotherapy and radiation therapy for oropharyngeal squamous cell carcinoma. Head Neck, 33: 1727–1734. doi: 10.1002/hed.21657
- Issue published online: 11 NOV 2011
- Article first published online: 18 JAN 2011
- Manuscript Accepted: 23 SEP 2010
- Manuscript Revised: 2 SEP 2010
- Manuscript Received: 25 JUL 2010
- squamous cell carcinoma;
The purpose of this study was to elucidate factors associated with pharyngoesophageal strictures after treatment for head and neck squamous cell carcinoma (SCC).
We conducted a retrospective review of patients receiving cisplatin and 5-fluorouracil chemotherapy combined with concurrent hyperfractionated radiation therapy for oropharyngeal squamous cell carcinoma.
Strictures developed in 13 of 67 patients (19%). Strictures were associated with tumor location (tonsil vs base of tongue; p = .03), neck dissection after completion of therapy (p = .03), and the duration of treatment-induced mucositis (weeks with mucositis grade ≥2; National Cancer Institute (NCI) Common Toxicity Criteria; p < .001). Age, sex, race, tumor stage, nodal stage, American Joint Committee on Cancer (AJCC) stage, human papillomavirus (HPV) status, smoking, radiation dose, maximum severity of mucositis, amifostine use, and pretreatment swallow dysfunction were not significantly associated with stricture. In multivariate analysis, only duration of mucositis, after controlling for age, sex, and tumor location, remained highly significant (p < .01).
The duration of treatment-related mucositis is an independent risk factor for stricture formation in patients with oropharyngeal SCC treated with concurrent chemotherapy and radiation therapy. © 2011 Wiley Periodicals, Inc. Head Neck, 2011