Role of prophylactic thyroidectomy in RET 790 familial medullary thyroid carcinoma
Version of Record online: 17 JUN 2011
Copyright © 2011 Wiley Periodicals, Inc.
Head & Neck
Volume 34, Issue 4, pages 493–498, April 2012
How to Cite
Bihan, H., Baudin, E., Meas, T., Leboulleux, S., Al Ghuzlan, A., Hannoteaux, V., Travagli, J.-P., Valleur, P., Guillausseau, P.-J., Cohen, R. and for the French Group of Endocrine Tumors (GTE) (2012), Role of prophylactic thyroidectomy in RET 790 familial medullary thyroid carcinoma. Head Neck, 34: 493–498. doi: 10.1002/hed.21763
- Issue online: 3 MAR 2012
- Version of Record online: 17 JUN 2011
- Manuscript Accepted: 24 JAN 2011
- Manuscript Revised: 14 DEC 2010
- Manuscript Received: 6 MAY 2010
- medullary thyroid carcinoma;
- RET 790 mutation;
- prophylactic thyroidectomy;
- multiple endocrine neoplasia
We describe a family harboring RET 790 mutation and review the role of prophylactic thyroidectomy for medullary thyroid carcinoma.
We evaluated in detail both clinical and biological follow-up and reviewed literature reports.
Among 86 family members, 15 of 22 members screened harbored the 790 mutation. Abnormal calcitonin levels were found in 8/15. Total thyroidectomy with lymph node dissection cured the 5 operated patients (range, 45–76 years). Tumor staging was pT1N0M0. Among 10 carriers who did not undergo surgery, 3 patients had abnormal calcitonin levels. For the others, calcitonin levels remained <30 pg/mL. Two asymptomatic carriers were older than 70 years. Four subjects were lost to follow-up.
In RET codon 790 mutations families, a case-by-case decision instead of systematic prophylactic thyroidectomy should be discussed. Difficulties of follow-up should be taken into account and represent the main challenge. © 2011 Wiley Periodicals, Inc. Head Neck, 2012