Selection of irrigation fluid to eradicate free cancer cells during head and neck cancer surgery
Article first published online: 8 JUL 2011
Copyright © 2011 Wiley Periodicals, Inc.
Head & Neck
Volume 34, Issue 4, pages 546–550, April 2012
How to Cite
Hah, J. H., Roh, D. H., Jung, Y. H., Kim, K. H. and Sung, M.-W. (2012), Selection of irrigation fluid to eradicate free cancer cells during head and neck cancer surgery. Head Neck, 34: 546–550. doi: 10.1002/hed.21773
- Issue published online: 3 MAR 2012
- Article first published online: 8 JUL 2011
- Manuscript Accepted: 1 FEB 2011
- Manuscript Revised: 13 JAN 2011
- Manuscript Received: 7 DEC 2010
- Seoul National University Hospital. Grant Number: 0420060260
- free cancer cell;
- tumor growth;
- wound contamination
Free cancer cells can be spilled out from exposed tumors or ruptured tumors. We examined the cytocidal effect of various irrigation fluids on free cancer cells in an animal wound model mimicking head and neck surgery.
Cancer cell–contaminated wounds were made with C3H/HeJ mice and syngeneic squamous cell carcinoma (SCC VII) cells. Distilled water, 5% povidone–iodine, 1.5% H2O2, normal saline, and cisplatin were used to irrigate for 5 minutes. In vitro tumor growth assays were done with different concentrations and exposure times of povidone–iodine and distilled water.
In the animal study, povidone–iodine significantly inhibited tumor growth. Povidone–iodine caused substantial inhibition of in vitro tumor growth, even at the concentration of 0.05%. After 30 seconds of exposure to 1% povidone–iodine, cancer cells were completely inhibited.
Povidone–iodine could be selected preferentially for the irrigation fluid during head and neck surgery, especially when the wound is suspected of cancer cell contamination. © 2011 Wiley Periodicals, Inc. Head Neck, 2012