Interleukin-23 receptor polymorphism as a risk factor for oral cancer susceptibility
Article first published online: 29 JUN 2011
Copyright © 2011 Wiley Periodicals, Inc.
Head & Neck
Volume 34, Issue 4, pages 551–556, April 2012
How to Cite
Chien, M.-H., Hsin, C.-H., Shih-Shen Chou, L., Chung, T.-T., Lin, C.-H., Weng, M.-S., Chou, M.-Y., Chen, M.-K. and Yang, S.-F. (2012), Interleukin-23 receptor polymorphism as a risk factor for oral cancer susceptibility. Head Neck, 34: 551–556. doi: 10.1002/hed.21779
- Issue published online: 3 MAR 2012
- Article first published online: 29 JUN 2011
- Manuscript Accepted: 15 FEB 2011
- National Science Council, Taiwan. Grant Number: NSC97-2314-B-040-025-MY3
- National Science Council, Ministry of Education, and Chung–Shan Medical University
- IL-23 receptor;
- genetic polymorphism;
- oral cancer
The purpose of this study was to evaluate the influence of genetic polymorphisms of interleukin (IL)-23 and the IL-23 receptor (IL-23R) on the susceptibility to oral cancer.
Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to measure polymorphisms of these genes in 240 controls and 240 patients with oral cancer.
Individuals with at least 1 varied C allele of rs10889677 (IL-23R polymorphism) had a 1.553-fold risk (95% confidence interval [CI], 1.073–2.241) of developing oral cancer compared with patients with the wild-type A/A homozygote. Patients with oral cancer with at least 1 varied C allele of rs10889677 had a 1.931-fold risk of tumor lymph node metastasis compared with patients with the C/C homozygote.
The varied C allele of the IL-23R gene may be considered a factor contributing to increased susceptibility and may be a predictive factor for tumor lymph node metastasis in Taiwanese with oral cancer. © 2011 Wiley Periodicals, Inc. Head Neck, 2012