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Interleukin-23 receptor polymorphism as a risk factor for oral cancer susceptibility

Authors

  • Ming-Hsien Chien PhD,

    1. Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan
    2. Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
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  • Chung-Han Hsin MD, PhD,

    1. Department of Otolaryngology, Chung Shan Medical University Hospital, Taichung, Taiwan
    2. School of Medicine, Chung Shan Medical University, Taichung, Taiwan
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  • Lin Shih-Shen Chou PhD,

    1. School of Dentistry, Chung Shan Medical University, Taichung, Taiwan
    2. Department of Dentistry, Chung Shan Medical University Hospital, Taichung, Taiwan
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  • Tsung-Te Chung MD,

    1. Department of Otolaryngology, Show Chwan Memorial Hospital, Changhua, Taiwan
    2. Institute of Medicine, Chung Shan Medical University, 110 Chien-Kuo N. Road, Section 1, Taichung 402, Taiwan
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  • Chien-Huang Lin PhD,

    1. Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
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  • Meng-Shih Weng PhD,

    1. Department of Nutritional Science, Fu-Jen Catholic University, Taipei 242, Taiwan
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  • Ming-Yung Chou PhD,

    1. School of Dentistry, Chung Shan Medical University, Taichung, Taiwan
    2. Department of Dentistry, Chung Shan Medical University Hospital, Taichung, Taiwan
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  • Mu-Kuan Chen MD, PhD,

    1. School of Medicine, Chung Shan Medical University, Taichung, Taiwan
    2. Department of Otorhinolaryngology–Head and Neck Surgery, Changhua Christian Hospital, Changhua, Taiwan
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  • Shun-Fa Yang PhD

    Corresponding author
    1. Institute of Medicine, Chung Shan Medical University, 110 Chien-Kuo N. Road, Section 1, Taichung 402, Taiwan
    2. Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan
    • Institute of Medicine, Chung Shan Medical University, 110 Chien-Kuo N. Road, Section 1, Taichung 402, Taiwan
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Abstract

Background

The purpose of this study was to evaluate the influence of genetic polymorphisms of interleukin (IL)-23 and the IL-23 receptor (IL-23R) on the susceptibility to oral cancer.

Methods

Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to measure polymorphisms of these genes in 240 controls and 240 patients with oral cancer.

Results

Individuals with at least 1 varied C allele of rs10889677 (IL-23R polymorphism) had a 1.553-fold risk (95% confidence interval [CI], 1.073–2.241) of developing oral cancer compared with patients with the wild-type A/A homozygote. Patients with oral cancer with at least 1 varied C allele of rs10889677 had a 1.931-fold risk of tumor lymph node metastasis compared with patients with the C/C homozygote.

Conclusion

The varied C allele of the IL-23R gene may be considered a factor contributing to increased susceptibility and may be a predictive factor for tumor lymph node metastasis in Taiwanese with oral cancer. © 2011 Wiley Periodicals, Inc. Head Neck, 2012

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