Original Article

Chondrocytes suspended in modified fibrin glue for vocal fold augmentation: An in vitro study in a porcine larynx model

  1. Daniel Skodacek MD1,*,
  2. Ulrike Arnold MD2,
  3. Katharina Storck MD1,
  4. Carmelo Perez Alvarez MD3,
  5. Sabine Ratzinger PhD3,
  6. Rainer Staudenmaier MD1

Article first published online: 29 JUN 2011

DOI: 10.1002/hed.21789

Issue

Head & Neck

Head & Neck

Volume 34, Issue 5, pages 667–673, May 2012

Additional Information

How to Cite

Skodacek, D., Arnold, U., Storck, K., Alvarez, C. P., Ratzinger, S. and Staudenmaier, R. (2012), Chondrocytes suspended in modified fibrin glue for vocal fold augmentation: An in vitro study in a porcine larynx model. Head Neck, 34: 667–673. doi: 10.1002/hed.21789

Author Information

  1. 1

    Department of Otorhinolaryngology, Klinikum rechts der Isar, TU München, Munich, Germany

  2. 2

    Department of Operative Dentistry and Periodontology, University Hospital Regensburg, Germany

  3. 3

    Department of Otorhinolaryngology, University Hospital Regensburg, Regensburg, Germany

*Department of Otorhinolaryngology, Klinkum rechts der Isar, TU München, Munich, Germany

Publication History

  1. Issue published online: 6 APR 2012
  2. Article first published online: 29 JUN 2011
  3. Manuscript Accepted: 22 FEB 2011

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Abstract

Background

Injection laryngoplasty is an option for treatment of dysphonia following vocal fold paralysis. Modified fibrin glue with suspended chondrocytes might be a favorable cell-based material for permanent vocal fold medialization.

Methods

We compared fibrin glue with suspended chondrocytes to collagen and hyaluronic acid gels concerning alteration of vocal fold vibration and correct intralaryngeal placement after intralaryngeal injection into porcine larynges. Viscoelastic properties of the materials were analyzed by means of a parallel plate rheometer.

Results

Fibrin glue with cells was comparable to collagen and hyaluronic acid with respect to amplitudes, symmetry, and periodicity of vocal fold vibration. Application and positioning of fibrin glue with suspended chondrocytes were technically undemanding and comparable with controls. Complex stress modulus of fibrin glue with suspended cells was comparable to that of collagen gel.

Conclusions

Fibrin glue with suspended chondrocytes seems suitable for the indication of injection laryngoplasty and holds promise for permanent vocal fold medialization. © 2011 Wiley Periodicals, Inc. Head Neck, 2012

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