This research was unfunded; it was supported by the University of New Mexico Cancer Center, Albuquerque, New Mexico.
Relationship of protein and calorie intake to the severity of oral mucositis in patients with head and neck cancer receiving radiation therapy†
Article first published online: 20 JUN 2011
Copyright © 2011 Wiley Periodicals, Inc.
Head & Neck
Volume 34, Issue 5, pages 655–662, May 2012
How to Cite
Zahn, K. L., Wong, G., Bedrick, E. J., Poston, D. G., Schroeder, T. M. and Bauman, J. E. (2012), Relationship of protein and calorie intake to the severity of oral mucositis in patients with head and neck cancer receiving radiation therapy. Head Neck, 34: 655–662. doi: 10.1002/hed.21795
- Issue published online: 6 APR 2012
- Article first published online: 20 JUN 2011
- Manuscript Accepted: 22 FEB 2011
- head and neck cancer;
The purpose of this study was to evaluate the relationship of calorie and protein intake to the severity of oral mucositis in patients with head and neck cancer receiving radiation therapy.
Patients with head and neck cancer undergoing ≥60 Gy of radiation were eligible. Weekly data were collected for oral mucositis grade and protein and calorie intake. Proportional odds models examined the association of oral mucositis severity with nutritional predictors.
During a 24-month period, 40 evaluable patients met criteria for inclusion. In a multivariate backward selection model, the sole significant nutritional predictor of reduced oral mucositis severity was meeting the protein goal for the current week (p = .01; adjusted odds ratio [OR], 2.30).
Patients who met protein-related goals during radiotherapy for head and neck cancer had less severe oral mucositis. Nutritional counseling during radiotherapy, with emphasis on protein goals, may reduce oral mucositis severity. © 2011 Wiley Periodicals, Inc. Head Neck, 2012